Structure | |
Storage | -20°C |
Molecular Formula | C41H77NO4 |
CAS No. | 127512-29-2 |
Appearance | Colorless to light yellow liquid |
Description | DODAP (1,2-dioleoyl-3-dimethylammonium-propane) is an ionizable cationic lipid with lower cytotoxicity and high transfection efficiency. DODAP is neutral at physiological pH, but acquires a positive charge inside the endosome due to the protonation of free amines when pH is lower than its pKa (<7). The electrostatic interactions between DODAP and naturally occurring anionic lipids in endosomal membranes trigger the release of nucleic acid. These interactions promote membrane lytic non-bilayer structures to enable the intracellular delivery of nucleic acid. A common application is in nanomedicine as an ionizable lipid component of nanocarriers (lipid-polymer hybrid nanoparticles, LPNs), widely used to encapsulate bioactive molecules, including mRNA, siRNA, and plasmid DNA as a treatment for diseases. |
Formula Weight | 648.05 g/mol |
Catalog: CDDTSL24-019-L
Catalog: CDDTSL24-014-L
Catalog: CDA24-091-L
Catalog: CDL23-005L
Catalog: CDTSL24-006-L
Catalog: CDDTSL24-013-L
Catalog: CDTSL24-042-L
Catalog: CDCCL24-010-L
1. Download the template.
2. Enter product information on the template (maximum number of products: 200).
3. Load the file using selector below.
1. Download the template.
2. Enter product information on the template (maximum number of products: 200).
3. Load the file using selector below.