Anti-Tenascin-C (TN-C) Aptamer Synthesis and Modification Service

CD Bioparticles offers anti-TN-C aptamer synthesis and modification services. Our many years of experience in custom aptamer design and modification will ensure that you have the best chance of obtaining aptamer customization for a high-affinity target protein suitable for your application. Our team has developed a variety of aptamers that can bind to cell surface receptors, providing the basis for aptamer target delivery studies for drugs.

Introduction to Anti-TN-C Aptamers

Tenascin-C (TN-C) is a hexameric, multimodal extracellular matrix protein that comes in several molecular forms and is produced through alternative splicing and protein modifications. It is highly conserved in vertebrates and molecular phylogenetics suggests that it evolved prior to fibronectin.

Tenascin-C directly affects cell phenotype through its interaction with cell surface receptors. It is overexpressed in the tumor stroma and is thought to enhance angiogenesis and invasion. Exploiting the pathological expression and function of tenascin-C is emerging as a promising strategy for the development of new diagnostic, therapeutic, and bioengineering tools.

Studies have shown that anti-TN-C aptamers can be used to target tumors expressing high levels of TN-C (glioma, breast and colon) and that nucleic acid aptamers may often have pharmacological properties that make them excellent agents for tumor-specific drug delivery.

Fig. 1 Structure of tenascin C. (Fu Z, et al., 2022)

Our Anti-TN-C Aptamer Services

CD Bioparticles specializes in the development of synthesis and modification of targeted drug delivery aptamers and utilizes our core technologies to customize aptamers for targeted drug delivery. With our high-quality products and services, you can significantly improve the progress of your experimental studies.

Our team can provide services for the study of targeted drug delivery systems from the construction of aptamers to the modification of aptamers. We can also design and customize experimental protocols according to your wishes.

Our services focus on but are not limited to, the following:

Our Anti-TN-C Aptamer Advantages

• Highly targeted: Synthesized and modified aptamers with high affinity and specificity facilitate the precise delivery of drugs to diseased tissues or cells, thus improving therapeutic efficacy and reducing unwanted side effects of drugs.
• Personalised therapeutic studies: By customising the structure and sequence of the aptamer, it is possible to personalise the treatment for different patients or different lesions, thus improving the therapeutic effect.
• Efficient: compared to conventional drug delivery systems, aptamer-delivered drugs have higher targeting and better biocompatibility, allowing for better therapeutic results at lower drug dosages.
• Highly controllable: By changing the structure and modification of the aptamer, controlled drug release can be achieved, resulting in improved therapeutic efficacy and safety.

Contact us

CD Bioparticles' expert team will provide one-stop support for every step of the targeted drug delivery aptamer synthesis and modification service, from aptamer screening synthesis to final aptamer modification. You will be notified of our progress when a phase of the study is completed. If you have any questions during this process, please feel free to contact us and we will ensure that you are kept informed.

Quotations and Ordering

Reference

1. Fu Z, Zhu G, Luo C, et al. Matricellular protein tenascin C: Implications in glioma progression, gliomagenesis, and treatment. Front Oncol. 2022; 12: 971462.