Aptamer and Nanocarrier Coupling Pharmacokinetic Study Service
Pharmacokinetics is the quantitative study of the dynamics of drug absorption, distribution, metabolism, and excretion in living organisms. It also elucidates the relationship between drug concentration and time at different sites. he intracellular drug disposal process and the binding of the drug to the target are the determinants of the therapeutic effect of a drug. Therefore, for drugs whose targets are located at specific cell sites, it is sometimes more meaningful to study the intracellular/subcellular drug concentration time-dependent process than the plasma drug concentration time-dependent process.
CD Bioparticles provides pharmacokinetic studies of aptamer-nanocarrier coupling, which can provide a comprehensive understanding of the mechanism of action of aptamer-nanocarrier coupling in drug-delivery cells and provide an important reference for the pre-design of aptamers.
Aptamer Coupling Pharmacokinetic Study Service Background
Cellular pharmacokinetics is the science of studying the kinetics of drug uptake, transport, distribution, metabolism and excretion in cells and sub-cells by considering the cell as a microscopic organism, and then elucidating the intracellular disposition of drugs through mathematical modeling.
Aptamer-nanocarrier targeted drug delivery systems are currently a hot topic for research on new drug delivery systems. Compared with free drugs, aptamer-nanocarrier drug delivery exhibits characteristics such as slow and controlled release and targeting, which can improve drug bioavailability and reduce toxic side effects; its entry and transmembrane pathways and pharmacological mechanisms are also different from those of free drugs.
At the current stage of aptameric drug development, it is the pharmacokinetics which mainly defines the therapeutic doses of the aptamers.
Our Aptamer Coupling Pharmacokinetic Study Services
CD Bioparticles specializes in pharmacokinetic studies of aptamer and nanocarrier coupling and utilizes our core technology to enable aptamer and nanocarrier coupling design services. With our high-quality services, you can significantly improve the progress of your experimental studies.
Our scientists can provide services from the coupling of aptamers with nanocarriers to the pharmacokinetic study of targeted drug delivery after coupling, and can tailor our experimental protocols and services to your needs. The pharmacokinetic studies we offer include, but are not limited to, the following:
Absorption and transport
Distribution and metabolism
Excretion
Advantages of Our Service
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Aptamer and nanomaterial coupling for synergistic therapy
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Inherent properties of nanomaterials enhance diagnostic and imaging sensitivity
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Provides an ideal platform for drug delivery
CD Bioparticles has many years of experience in the pharmacokinetic study of aptamer-nanocarrier coupling. As the types of nanomaterials have been studied in depth in recent years, many nanomaterials with excellent properties have different roles in targeted diagnostics and therapeutics. We can also combine several nanomaterials to explore their synergistic role in diagnostics and therapeutics to improve the efficiency of drug utilization. If you are interested in our services, please do not hesitate to contact us.
Quotations and Ordering
Reference
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Zavyalova E, Samoylenkova N, Revishchin A, et al. The Evaluation of Pharmacodynamics and Pharmacokinetics of Anti-thrombin DNA Aptamer RA-36. Front Pharmacol. 2017; 8: 922.
