Aptamer Targeted Drug Delivery System
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CD Bioparticles offers aptamer customization services for targeted drug delivery. Aptamers can be used not only as specific ligands for cancer diagnosis, but also in cancer treatment to improve therapeutic efficiency.
Our experienced scientists have created a comprehensive technical service platform to design aptamer systems for targeted drug delivery systems based on customer requirements.
Aptamers are single-stranded DNA or RNA molecules that have high affinity and specificity for the target molecule and can bind to the target molecule by folding into different secondary or tertiary structures.
The small and flexible structure of aptamers allows them to bind to smaller targets or some hidden structural domains that antibodies cannot bind to. Also, aptamers can act as carriers of drug delivery, precisely delivering drugs such as chemotherapeutic agents, therapeutic RNAs, toxins and radioisotopes to cancer cells, thus improving therapeutic efficiency. Therefore, it has attracted a lot of attention from scientists.
Fig.1 Schematic Diagram of Aptamer Function (Yang S, et al., 2018)
Our Featured Services
CD Bioparticles specializes in aptamer-targeted drug delivery system development services and utilizes our core technologies to conduct research for aptamer applications in cancer therapy. The services we can provide include, but are not limited to, those listed below:
Advantages of Aptamer Targeted Drug Delivery
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The aptamers can be screened in vitro against specific targets and, once screened successfully, can be synthesized in large quantities, avoiding the potential toxicity and immunogenicity of antibodies.
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Due to the small molecular weight and spatial size of the aptamer, it is easier to penetrate tissues and reach the target site.
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The aptamers have the heat-stable structure of nucleic acids and can reversibly shift their conformation.
For more on organ-targeted drug delivery systems, click on here.
Applications of Aptamers
Cell imaging: Fluorescently labeled aptamers or aptamer complexes are the basis for aptamer applications in cell imaging.
Drug delivery: Aptamers are able to bind specifically to targets, and nanomaterial-specific aptamer complexes enable targeted intracellular delivery of drugs.
For more on nanoparticle applications for drug delivery, click on here.
Disease treatment: Aptamers are a potential anticancer chemotherapeutic agent.
Microbial detection: Aptamers have been widely used in the detection of pathogenic bacteria.
Our Aptamer Advantages
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Experienced Scientists
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Most Advanced Instrumentation
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Highest Price Competitiveness
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Standardized Service Processes
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Personalized and Customized Service
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Customer Focus
CD Bioparticles has many years of experience in the field of aptamer-targeted drug delivery studies, and we provide fast turnaround, high-quality data reporting at competitive prices to our customers worldwide. Customers can contact our staff directly and we will respond promptly. If you are interested in our services, please contact us for more detailed information.
Quotations and Ordering
Reference
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Yang S,Li H,Xu L, et al. Oligonucleotide Aptamer-Mediated Precision Therapy of Hematological Malignancies. Mol Ther Nucleic Acids. 2018; 13: 164-175.
