Animal Model Construction
CD Bioparticles is a well-established drug delivery research company, equipped with laboratory personnel who have long been engaged in the development of animal experimental models and biological sample processing. Experimenters are familiar with all kinds of drug delivery methods and model construction, providing one-stop Non-GLP or GLP-grade animal experiment service for you.
Introduction to Animal Models
Animal disease models are mainly used for research in physiology and pathology, toxicology and pharmacology, and drug efficacy and pharmacokinetics. With the help of animal models to simulate human disease types, it is possible to consciously change those factors that are impossible or not easy to be excluded under natural conditions, so as to more accurately observe the experimental results of the models. Comparative studies with human diseases can help to understand more effectively the pattern of occurrence and development of human diseases and to study preventive and therapeutic measures.
CD Bioparticles has constructed more than a hundred animal disease models for tumors, diabetes, respiratory diseases, digestive diseases, immunodeficiency diseases, neurological diseases and reproductive diseases. We have an experienced team that can recommend the most suitable animal models according to the types of human diseases, including animal models of mice, rats, zebrafish, hamsters, pigs and monkeys, in order to achieve consistent evaluation of the constructed models and human diseases. Meanwhile, our experienced lab technicians, who are familiar with drug modeling (chemically induced modeling), surgical modeling, gene editing modeling, physical modeling, and exogenous cell injection modeling, can provide you with Non-GLP or GLP-grade animal experimental studies according to your needs. In addition, we can provide you with experimental tests related to animal models, such as animal behavioral assays, toxicology, pharmacokinetic studies, histopathology studies and mouse in vivo imaging, etc., to accelerate the commercialization value of your drugs.
Table 1. Characteristics and application of conventional experimental animal models.
| Experimental Animal Models |
Specificities |
Applications |
| Mouse |
Genetically similar to humans |
Cancer research |
| Short life |
Cardiovascular disease |
| Easy to breed and manage |
Diabetes |
| Physiological characteristics similar to humans |
Nervous system diseases |
| Widely used in genetics and immunology research |
Immunology and infectious diseases |
| Rat |
Larger than mice, suitable for some surgeries |
Cardiovascular disease |
| Suitable for specific surgical operations |
lung disease |
| Widely used in neuroscience and toxicology research |
Nervous system diseases |
| Zebrafish |
Transparent embryos for easy visualization |
Embryonic development |
| Rapid embryonic development |
Genetics and genomics |
| Suitable for studying organ development |
Neurodevelopment and function |
| Pig |
Larger, with physiological characteristics closer to those of humans |
Cardiovascular disease |
| Suitable for surgical and transplantation studies |
Organ transplant |
| The physiological characteristics of the digestive system are closer to those of humans |
Gastrointestinal diseases |
| Hamster |
Easy to carry and farm |
Lung disease |
| Suitable for certain cancer research |
Cancer research |
| Monkey |
Suitable for studying complex behavior |
Drug testing and preclinical trials |
| Physiological and neurological characteristics similar to humans |
Neuroscience and cognitive research |
Table 2. Different modalities of modeling and adapted diseases.
| Molding method |
Description |
Applications |
| Pharmacological Modeling |
Inducing a disease state by administering a specific drug or chemical to an animal |
Diabetes (high-sugar foods) |
| Liver disease (alcohol-induced) |
| Disease of the blood |
| Surgical Modeling |
Causing a specific pathology by surgical or other traumatic methods |
Myocardial ischemia (coronary ligation) |
| Cerebral ischemia (MCAO) |
| Ligation (ligation of organs) |
| Physical Modeling |
Triggering a specific physiological or pathological state through physical stimulation or injury |
Skin aging (UV-induced) |
| Mechanical damage to cartilage (mechanical irritation) |
| Insomnia (sleep deprivation) |
| Cell Injection Modeling |
Triggering tumor growth and progression by injecting exogenous cells (usually tumor cells) |
Tumor models (injected with human tumor cells or tissue) |
| Cancer research (using different types of cancer cell injections) |
| Gene Editing Modeling |
Utilizing KO, KI or CKO approaches to achieve specific pathologies |
Porcine model of dilated cardiomyopathy |
| Porcine model of type I tyrosinemia |
Types of Animal Model
- Tumours Disease Models
- Cardiovascular System Disease Models
- Digestive System Disease Models
- Skin Disease Models
- Endocrine and Nutritional Disease Models
- Genitourinary Disease Models
- Respiratory System Disease Models
- Inflammation Models
- Ophthalmology Models
- Ischaemia-reperfusion models
- Orthopaedic Pain Models
- Immune Disease Models
- Other Models Upon Request
Advantages of Animal Model
- Extensive resources and experience to meet your GLP and non-GLP needs
- Experienced project manager
- Hundreds of model types, more choices
- Able to provide integrated services from animal model construction to pharmacological and pharmacodynamic evaluation
- High delivery quality, controlled lead time and price advantage
Our Featured Services
CD Bioparticles has a full range of leading experts in animal modelling. We can offer you a wide range of services related to animal models based on different kinds of diseases:
- Construction of animal models of different kinds of diseases
- Experimental evaluation of animal models
Quotations and Ordering
Reference
- Luo G, et al.; Three-staged tumor inhibition by mitochondria-targeted cascaded gas/ mild-photothermal/photodynamic synergistic therapy. Chemical Engineering Journal. 2022, 442: 136169-136184.
