Nanoparticle Surface Functionalization
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Functionalization of side groups or end groups of nanoparticles is an important method of modifying nanomaterials. By introducing different chemical groups or functional groups on the surface of nanoparticles, its surface properties can be changed, such as enhancing its stability, or confer specific chemical or biological activity. This functionalization process usually involves steps of chemical synthesis or modification, and appropriate functional groups can be selected based on specific application requirements. CD Bioparticles is dedicated to cutting-edge nanotechnology research. We have created an advanced nanomaterial modification platform that can help you solve:
The challenges you might meet:
- Nanoparticles tend to aggregate in solution and lose their functionality
- Poor biocompatibility of nanoparticles
- Simple nanoparticles lack targeting properties
- Nanosensors constructed from unmodified nanoparticles are not sensitive enough
- Need to obtain nanoparticle systems with high catalytic activity
- Need to modulate and control the optical, electrical or magnetic properties of nanoparticles
- Nanoparticles used are difficult to trace
Figure 1. Main strategies for covalent post-functionalization of nanoparticles. (Pablo Froimowicz, et al.; 2013)
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- Carboxylation (-COOH)
- Amination (-NH2)
- Thiolation (-SH)
- Hydroxylation (-OH)
- Aldehyde (-CHO)
- Halogenated (-X)
- Epoxidation
- Coupling agent
- PEGylation
- Polylysine modification
- Maleimide modification
- Biotin modification
- Dextran modification
- Dibenzocyclooctyne (DBCO) modification
- Streptavidin modification
Key benefits:
- Customizability and controllability: Functionalization provides the ability to customize the surface of nanoparticles, allowing precise control of the chemistry, surface properties, and functionality of nanoparticles. This allows nanomaterials to be designed according to specific needs.
- Enhanced stability: Functionalization can enhance the stability of nanoparticles in different media and reduce their aggregation and precipitation, thereby improving the service life and performance of nanomaterials.
- Improved biocompatibility: For biomedical applications, functionalization can modify the surface of nanoparticles into a biocompatible form to reduce cytotoxicity and improve biocompatibility, making them more suitable for in vivo applications.
- Enhanced targeting: By introducing specific ligands or molecules on the surface of nanoparticles, targeted delivery can be achieved, allowing the nanoparticles to accurately locate specific cells, tissues or biomolecules, thereby improving therapeutic effects or diagnostic sensitivity.
- Creating multifunctional materials: Functionalization can enable nanoparticles to possess multiple properties and functions, such as multifunctional nanoparticles with simultaneous drug delivery, imaging, and therapeutic functions.
- Improving catalytic performance: Functionalizing catalytic nanoparticles can improve their catalytic activity and selectivity, thereby improving applications in areas such as chemical synthesis and environmental remediation.
- Building nanosensors: Functionalization can transform nanoparticles into highly sensitive sensors for detecting and monitoring molecules, biomolecules, or pollutants in the environment.
- Changing optical, electrical, and magnetic properties: Functionalization can tune the optical, electrical, or magnetic properties of nanoparticles to meet specific application needs, such as preparing high-performance sensors, optoelectronic devices, and magnetic materials.
- Exploring new fields: The functionalization of nanoparticles has expanded the application fields of nanomaterials, with broad application prospects in various fields from medicine to materials science, energy, environment, etc.
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CD Bioparticles is a globally recognized and trusted biotechnology company with a highly skilled team of scientists with many years of experience. We have outstanding capabilities in the fields of synthesis, modification and characterization of nanoparticles. You are welcome to contact us at any time, and our senior technical experts will provide you with detailed answers.
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References
- Pablo Froimowicz, et al.; Surface-Functionalized Particles: From their Design and Synthesis to Materials Science and Bio-Applications. Current Organic Chemistry. 2013, 17(9):900-912
- Abd Ellah NH, Abouelmagd SA. Surface functionalization of polymeric nanoparticles for tumor drug delivery: approaches and challenges. Expert Opin Drug Deliv. 2017, 14(2):201-214.
- Abdelkhaliq A, et al.; Impact of nanoparticle surface functionalization on the protein corona and cellular adhesion, uptake and transport. J Nanobiotechnology. 2018, 16(1):70.
