Supercritical Liposome Technology for Drug

CD Bioparticles specializes in the development and production of "liposomes", with its pioneering supercritical liposome technology offering novel solutions for enhancing therapeutic efficacy, preserving drug activity, and reducing adverse effects in active pharmaceutical ingredients within the biomedical industry.

Introduction to Supercritical Liposome Technology for Drug

Supercritical fluid technology, as an innovative product core layer technology, mainly includes supercritical particle crystallization technology, supercritical drying technology, supercritical chromatographic separation technology and supercritical complex separation. CD Bioparticles specially designed for nanoparticles, liposomes, microspheres, fat emulsions and other difficult to dissolve preparations of the supercritical particles of the engineering technology, has a simple process, high efficiency, low operating temperature, no solvent residue, high stability of product batches, quality control consistency and other characteristics. Especially in the application of nanomedicine, it will greatly enhance the retention of active ingredients. By adopting supercritical process, what is made is harmless to human body and retains the original quality and characteristics of the substance, which is especially suitable for dealing with high-boiling point heat-sensitive substances.

Figure 1. Simplified mechanism of simultaneous microencapsulation in liposomes using the eco-friendly SCF process. (Tsai W, et al.; 2017)

Supercritical Liposome Technology for Drug Applications

• Pharmaceutical field: especially suitable for dealing with heat-sensitive, easy to oxidize drugs, as well as improve the oral absorption of insoluble drugs
• Nutritional health food: production of uniform and stable liposomes (e.g. flaxseed oil nanoliposomes)

Supercritical Liposome Technology Advantages

• Improving bioavailability
• Controlled release
• Uniform particle size
• Cost advantage. Simple process, low comprehensive cost
• Stable technology, good reproducibility from small trial to scale-up production
• In the supercritical state, the product is directly dry powder, without drying step
• Oxygen-free environment, low working temperature, to achieve the protection of heat-sensitive, easy to oxidize active ingredients

Supercritical Liposome Technology Customized Services that CD Bioparticles Can Provide:

1. Feasibility Study

• Pre-formulation studies

2. Formulation Development

• Supercritical liposomal encapsulation
• Optimisation of liposome size and surface charges
• Scalability studies

3. Analytical and Characterisation Services

• Particle size analysis
• Zeta potential measurement
• Encapsulation efficiency
• Drug release performance studies

4. Stability Studies of Supercritical Liposome Drug

• Accelerated stability testing
• Real-time stability testing

5. Scale Up

• Pilot-scale production
• GMP production

CD Bioparticles is a biological company specializing in liposome research with a team of skilled scientists and years of experience. We are committed to improving the stability of solved actives, extending the shelf life of actives, and increasing the bioavailability of actives. Our R&D team also develops customized liposome formulations to meet specific customer needs. Our high-end liposomal API are guaranteed by our scientific background and innovative technologies.

Reference

1. Tsai W, et al.; Simultaneous microencapsulation of hydrophilic and lipophilic bioactives in liposomes produced by an ecofriendly supercritical fluid process. Food Res Int. 2017, 99(1): 256-262.