Preparation of Degeredable Polyprolactone Polymer (PCL)/Magnetic nanocomposite for Drug Delivery Systems Against Anticancer Compounds

Nikzamir, N; Khojasteh, H; Vakili, MN; Azimi, C; Ghanbari, E

Abstract

Magnetic nanoparticles have been used primarily for medical advances, chemotherapy, and specialized tissue repair for targeted drug delivery. In this research, magnetic iron nanoparticles were first prepared and identified. Then, biodegradable copolymer of polypro-pylene caprolactone-polyethylene glycol PCL-PEG1000-PCL was synthesized. Doxorubucin nanoparticles were prepared by using copolymer containing magnetic nanoparticles by solvent-evaporation method. VSM, FT-IR, UVvis, 1H-NMR and SEM were used to determine the structural properties of copolymer nanoparticles. The synthesis of PCL-PEG1000-PCL triple block copolymer and doxorubicin and iron nanoparticles encapsulation were confirmed by the mentioned characterization methods. The resulting nanoparticles have superparamagnetic properties and the drug encapsulation yield was about 95%. The effect of pH and heat on drug release curve was investigated. The results showed that the copolymer synthesized is suitable for the encapsulation of doxorubicin and iron nanoparticles and can be effective as a carrier of novel nanostructures in the delivery of anticancer drugs. The results showed that due to the properties of magnetic nanoparticles and copolymers they can be used for targeted drug delivery for targeted drug delivery.

Keywords: Anticancer; Doxorubicin; Drug Delivery; Magnetic Nanoparticles; Poly Caprolactone Copolymer

Related products/services

Poly(caprolactone)s

Polycaprolactone (PCL) is a biodegradable polymer that has garnered significant attention in the field of drug delivery systems, particularly for anticancer compounds. PCL's unique properties, including its biocompatibility, slow degradation rate, and ease of processing, make it an ideal candidate for creating sustained-release drug delivery vehicles. PCL nanoparticles can encapsulate anticancer drugs, protecting them from premature degradation and ensuring controlled release at the tumor site. This targeted delivery not only enhances the therapeutic efficacy of the drugs but also minimizes systemic side effects and toxicity. Furthermore, PCL's versatility allows for the incorporation of various drug molecules, whether hydrophilic or hydrophobic, broadening its application scope. Recent advancements in PCL-based drug delivery systems have demonstrated improved bioavailability and tumor targeting, presenting a promising approach to enhancing cancer treatment outcomes. By leveraging PCL's properties, researchers can develop more effective and safer anticancer therapies.