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Metal-organic Frameworks and Novel Drug-Carrying Systems
Metal-organic frameworks (MOFs) form long-range ordered geometric structures through the coordination and binding of metal ions and small organic molecules, changing metal elements and small organic molecules, resulting in an ever-expanding family of MOFs. Due to their excellent properties such as low density, high specific surface area, high porosity, tunable pore size and morphology, and topological diversity, MOFs have broad application prospects in the field of drug delivery. As a drug carrier, MOFs can not only protect the drug, but also improve the human body’s absorption, release and metabolism of the drug, and enhance the therapeutic effect of the drug, which has potential advantages. Introduction to MOFs In 1995, Yaghi…
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Researchers Stabilize the Collapsing Metal-organic Frameworks by Adding a Polymer
High internal surface area is a highly sought after asset in material design, bringing metal-organic frameworks (MOFs) at the forefront of materials research. In fact, the main focus in this field is to create innovative methods to maximize the surface area of the MOF. Nevertheless, macroporous MOFs, especially those with mesopores, still face the problem of pore collapse during activation. In a study published in the Journal of the American Chemical Society, the researchers have solved this problem by adding a small amount of polymer to the MOF pores, which prevents the pores from collapsing. MOFs are a special kind of sponge-like materials with nano-scale pores which have many applications, such as carbon capture…
