Regarding the research progress of self-assembled drug delivery systems, we have introduced the clinical research on acyclovir and didanosine self-assembled systems in previously article. This article will continue to introduce the research results of other drug self-assembly systems, such as zidovudine, isoniazid and gemcitabine self-assembly drug delivery systems. Zidovudine Zidovudine (AZT) is the first anti-HIV drug to be marketed and is still the first-line drug. Nano-preparations of zidovudine include liposomes and nanoparticles.  As they may obtain the property of sustained release, lymphatic targeting, and macrophage system targeting,these nano preparations can reduce or eliminate the bone marrow toxicity caused by the distribution of zidovudine in the bone marrow tissue. Since zidovudine, as nucleoside analogs, must be…

The current research on self-assembled drug delivery system (SADDS) mainly uses nucleoside analogue antiviral drugs, antituberculosis drugs, and antitumor drugs as model drugs, which covalently combine with various long-chain lipid molecules to form amphiphilic prodrugs. Then it is dispersed into water by a certain method (mainly injection method) to form a highly dispersed aggregate. Aggregates are generally nanostructures, and their shapes can be vesicles, nanoparticles, nanotubes, etc. One of the advantages of nanoassemblies or nanostructures is that they can circulate in the blood relatively freely and can produce targeting effects. Sometimes certain polymers can be added to increase system stability. These self-assemblies have strong targeting of liver, lung, and spleen…

In the first article on Pharmcosomes published in 1986, the researchers prepared the succinyl pindolol monostearoyl glyceride maleate pharmacosome. After being placed, the particle size can become larger, the chemical stability is good, and there is no degradation within 2 months, and the half-life of the drug substance is equivalent to that of the free drug; the oral drug substance is also basically the same as the free drug. The distribution of the drug in the body conforms to the one-compartment model, but unfortunately the author did not study it further. Because the explanation of pharmacosomes is too simple, there is no theory, and there are few related researches. For a long period of time,…