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Research Progress Of Self-Assembled Drug Delivery Systems I
The current research on self-assembled drug delivery system (SADDS) mainly uses nucleoside analogue antiviral drugs, antituberculosis drugs, and antitumor drugs as model drugs, which covalently combine with various long-chain lipid molecules to form amphiphilic prodrugs. Then it is dispersed into water by a certain method (mainly injection method) to form a highly dispersed aggregate. Aggregates are generally nanostructures, and their shapes can be vesicles, nanoparticles, nanotubes, etc. One of the advantages of nanoassemblies or nanostructures is that they can circulate in the blood relatively freely and can produce targeting effects. Sometimes certain polymers can be added to increase system stability. These self-assemblies have strong targeting of liver, lung, and spleen…
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Injection Nano Drug Delivery System II
As mentioned above, liposomes, microemulsions and nanoemulsions are used for pharmaceutical transportation through the injection of nanometer drug delivery system. And this article will further introduce other nano-carriers that can be administered by injection nano-administration, including: nanoparticles, polymer micelles, nanogels, polymer complexes, and nanosuspensions. Nanoparticles Nanoparticles, as a carrier for the injection of nano-drug delivery systems, have their advantages mainly in: 1. The more hydrophilic the surface of the surface-modified nanoparticles, the smaller the uptake by macrophages. 2. The in vitro release of drugs can be adjusted by controlling the increase in PEG molecular weight and content or the decrease in copolymer molecular weight. 3. The distribution of nanoparticles in…
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Self-Assembled Drug Delivery Systems
In the first article on Pharmcosomes published in 1986, the researchers prepared the succinyl pindolol monostearoyl glyceride maleate pharmacosome. After being placed, the particle size can become larger, the chemical stability is good, and there is no degradation within 2 months, and the half-life of the drug substance is equivalent to that of the free drug; the oral drug substance is also basically the same as the free drug. The distribution of the drug in the body conforms to the one-compartment model, but unfortunately the author did not study it further. Because the explanation of pharmacosomes is too simple, there is no theory, and there are few related researches. For a long period of time,…
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Injection Nano Drug Delivery System 1
Injection administration is to inject drugs into the body through injection to achieve the purpose of preventing and treating diseases. There are three ways of injection administration: intravenous (IV), intramuscular (IM) and subcutaneous (SC). Each has its own advantages and disadvantages. Different injection methods should be selected according to the specific situation. Liposomes Liposomes are vesicles sealed by a bilayer of phospholipids, similar to the cell structure, with an internal aqueous phase that can encapsulate water-soluble drugs. The inside of the lipid bilayer is fat-soluble and can encapsulate fat-soluble drugs, but the capacity is limited. According to the particle size, liposomes can be divided into small unilamellar vesicles (SUV, 30~100nm),…
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Cardiovascular Drug Liposome
Cardiovascular disease, also known as circulatory system disease, is a disease with high human mortality. Approximately 17 million people die from cardiovascular disease worldwide each year. Cardiovascular and cerebrovascular diseases mostly occur after the age of 40. There are more men than women, and more mental workers than manual workers. The average prevalence is about 6.49%, and the prevalence increases with age. Affected by the high-fat, fast-paced, and high-stress lifestyle, the prevalence of cardiovascular and cerebrovascular diseases is increasing year by year, and the age of illness tends to be younger. Cardiovascular disease has become a major global medical problem. According to the mechanism of action, drugs for the treatment of cardiovascular diseases can be divided…
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Biotechnology Drug Liposome
In recent years, the development of biotechnology drugs has been advancing by leaps and bounds. Many biotechnology products have been widely used in clinics, and their application value has attracted more and more attention. A survey conducted in the United States from August 1993 to March 1995 showed that the number of biotech drugs listed as clinical trials increased by 64% in less than two years. Cancer is the disease with the most applications of biotechnology products. Other diseases involved include AIDS, amyotrophic lateral sclerosis, asthma, diabetes, heart disease, Lyme disease, multiple sclerosis, rheumatoid arthritis, stroke, and viral infections , Wound healing, inhibit organ transplant rejection. The types of biotechnology products include cytokines, monoclonal antibodies,…
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Quality Control Of Liposomes 2
As a promising drug carrier, liposomes require strict quality control for clinical use. In the previous article, we have introduced the requirements and methods of liposome morphology and particle size control. This article will introduce other parameters involved in liposomes as drug carriers，including: encapsulation rate, oxidation index, lysophospholipid, drug content, leakage rate, osmotic pressure and sterilization conditions. Encapsulation Efficiency Encapsulation efficiency is an important indicator to measure the quality of liposomes. It refers to the ratio of the encapsulated drug to the total amount of drug in the liposome suspension. The key to determining the encapsulation efficiency is to separate the unencapsulated free drug from the liposome suspension without destroying the…
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What Is The Antiviral Drug Liposome?
Viruses are the smallest kind of pathogenic microorganisms. They reproduce in cells. The core is ribonucleic acid (RNA) or deoxyribonucleic acid (DNA), and the outer shell is protein, which does not have a cell structure. The virus parasitizes in the host cell and relies on the host cell metabolic system for proliferation and replication. Statistics show that about 60% of epidemics are caused by viral infections. The research and development of antiviral drugs has naturally become a hot spot for investment in the pharmaceutical industry. Until now, there is still a lack of specific drugs for the treatment of viral diseases. The clinically commonly used drugs mainly include the following…
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Quality Control Of Liposomes 1
As a drug carrier, liposome not only improves the in vivo behavior of the drug, improves the therapeutic index of the drug, reduces the toxicity of the drug, and reduces the adverse reactions of the drug, and has a certain slow-release and controlled-release effect, reduces the dose or frequency of drug administration, and improves patient compliance . According to the characteristics of liposome formulations, the stability of liposomes has always been a concern of researchers. Liposomes are easy to aggregate, drugs are easy to leak (decrease in encapsulation rate) and oxidative deterioration will directly affect the safety and effectiveness of liposome drugs, so the quality of liposome drugs should be studied and…
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Liposome Preparation Method 2
Liposomes have attracted researchers’ attention because of their unique properties. Its successful application as a drug delivery carrier makes it a key research object in the field of drug delivery. There are already many methods for the preparation of liposomes, the above has introduced thin film method, reverse evaporation method, re-emulsion method and centrifugation method. Immediately above, this article focuses on the injection method, calcium fusion method, ammonium sulfate gradient method, and high-pressure homogenization. Injection Method Dissolve lipids in water-miscible or immiscible organic solvents, inject into the aqueous phase with a micro syringe at an appropriate rate, and remove organic solvents by ultrafiltration, dialysis, reverse osmosis, reduced-pressure evaporation, etc. as needed.…
