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Colon-Targeted Nanoparticles
The colon is located between the cecum and rectum and is divided into four parts: the ascending colon, the transverse colon, the descending colon, and the sigmoid colon. Its main function is to absorb water and electrolytes and solidify the contents into feces. The colon cannot actively absorb substances such as sugar, amino acids, and small molecule peptides. Its absorption function is mainly achieved by the content of the colon staying for a long time. Some drugs can be absorbed by passive diffusion. The physiological environment of the colon has the following characteristics: ① The pH is generally 6.5 to 7.5, which varies depending on the diet structure and physiological…
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Eye Targeted Nano Drug Delivery System
The eye is divided into anterior and posterior segments. The anterior segment includes the cornea, conjunctiva, iris, aqueous humor, and ciliary body. The posterior segment includes the vitreous, retina, choroid, and sclera. The physiological barriers of the eye include the corneal and conjunctival barriers, the aqueous humoral barrier, and the blood-retinal barrier. The cornea and retina are barriers that are not easily penetrated by drugs. The drug absorption of eye drops usually has a corneal route and a non-corneal route. Fat-soluble drugs enter the aqueous humor from tears mainly through the corneal pathway. In the non-corneal pathway, the drug penetrates into the human eye tissue through the conjunctiva and sclera,…
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Kidney-targeted Nanoparticles
Common kidney diseases include pathological changes in primary and secondary glomeruli, renal tubules, renal mediators, and renal blood vessels. In the clinical treatment of kidney disease, hormone shock treatment is often used, supplemented by triptolide tablets and other drugs for maintenance treatment. The toxic and side effects of large doses of hormones and maintenance drugs severely limit the continuous treatment of kidney disease. When kidney disease develops to a later stage, chronic renal failure will occur, and patients have to rely on expensive hemodialysis or kidney transplantation to prolong life, which will bring a heavy burden on patients’ families and society. It is of great significance to research and develop…
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Bone-targeting Nano-drug Delivery System
Bone is an important part of the human body and is composed of periosteum, bone and bone marrow. Normal bones are always in the dynamic equilibrium of bone formation and bone resorption in bone reconstruction, and they coordinate with each other to maintain the physiological functions of bones. If the pathological change occurs during normal bone reconstruction, various bone diseases such as osteoporosis, deformity osteitis, bone metastases, primary and secondary bone tumors, and osteoarthritis will occur. Due to the high hardness, poor permeability, and special physiological and biochemical processes of the bone tissue, it is difficult for the general route of administration to transport the drug to the lesion site.…
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The Mystery Of Cationic Nanocarrier Toxicity
With the application of nanotechnology in the field of medicine, lipid- or polymer-based nanocarriers are becoming the mainstream for delivering small-molecule drugs and large molecules, which has increased the effectiveness of drugs and simplified their administration. Nano-scale carriers not only The advantages of nanomaterials, as well as novel properties and functions, such as the ability to interact with complex cell functions in new ways, can create new biomedical applications. In addition, by designing physicochemical properties or surface modification, nanocarriers have multiple potentials for targeted drug delivery to specific sites. Among them, surface charge is one of the important characteristics of nanoparticles. Positively-charged nanocarriers formed from cationic lipids or polymers are most commonly used in…
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Nanoparticles Vector Can Screens Release Peptides For Efficient Gene Delivery
For many years, gene therapy has attracted the attention of scientists all over the world due to its nature of fundamentally treating diseases, in order to overcome genetic diseases such as cancer, diabetes, and multiple sclerosis. However, nucleic acid-based drugs, including transgene-containing plasmids, SiRNAs, antisense oligonucleotides, aptamers, and ribozymes, have not achieved the expected results in clinical trials. The reason is that some extracellular and intracellular barriers hinder the bioavailability of these drugs at their site of action. Therefore, a delivery system that can overcome these obstacles is necessary. Over the past few decades, scientists have developed viral and non-viral vectors to deliver genetic drugs into cells of the body.…
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How The Nano-Drug Delivery System Performs Brain Targeting
Brain diseases such as brain tumors, Alzheimer’s disease, Parkinson’s disease, central nervous system infections, chronic pain, drug addiction, periodic migraine, neurodegenerative diseases, epilepsy, and schizophrenia are the threat of human body and mind of improtant diseases of health. However, during the treatment process, the blood-brain barrier (BBB) prevents most drugs from entering the brain, resulting in poor drug effects. Brain targeted delivery of drugs to the brain is to use various techniques to promote the drug to break through the BBB into the brain. The current brain targeted delivery methods mainly include changing the physicochemical properties of the drug, preparing prodrugs, and carriers. Among them, nanocarriers have attracted much attention…
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How Integrin-Targeted Plaga-Chitosan Nanoparticles Are Used In Tumor Treatment
Since most chemotherapeutic drugs are toxic to normal cells, it is an important goal for cancer drug carrier development to achieve the appropriate concentration of therapeutic drugs at the location of cancer cells while reducing the exposure of normal cells to chemotherapeutic drugs. Chemotherapy is non-specific for normal cytotoxicity, mainly dose-dependent toxicity. Studies have found that targeted drug delivery systems show a higher affinity for tumor cells. Therefore, targeted nanoparticle-based drug delivery is a promising method to overcome this challenge. In lung cancer clinical studies, overexpressing receptors on cancer cell surfaces are often used as targets for therapeutic and ligand / antibody-modified nanodrug delivery vehicles. Previous studies have shown that…
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What Are The Advantages Of Nano Silver Particles In The Development Of Influenza Virus Drugs
Influenza virus is an orthomyxovirus. Its infection can cause severe respiratory diseases, which is not only a threat to human health as a result of serious individual infection or even death, but also a potential threat of rapid transmission between animals and humans, and between humans because the influenza virus can undergo frequent mutations and mutate into highly pathogenic strains. In ta huge economic he 20th century, there were several influenza pandemics in the world. All previous influenza outbreaks caused huge human and material losses to the world. Due to influenza worldwide, the number of direct deaths each year is 10,000 to 15,000, and the number of indirect deaths from…
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How Nanoparticles Promote The Development And Utilization Of Vaccines
Despite advances in conventional vaccines, improvements are still needed due to concerns about low toxicity, instability, and the need for multiple vaccination. To overcome these problems, nanotechnology has recently been incorporated into vaccine development. With the development of nanotechnology, nanotechnology is playing an increasingly important role in vaccine development, and nanocarriers provide opportunities to enhance cellular and humoral immune responses. The application of nanoparticles in vaccine formulations can not only enhance the immunogenicity and stability of the antigen, but also can target delivery and sustained release. In the past decade, nanoscale materials such as virus-like particles, liposomes, ISCOMs, polymers, inorganic nanoparticles, and emulsions have attracted attention as potential carriers of…
