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How The Liver-Targeted Nano-Drug Delivery System Is Realized
Physiological characteristics of the liver The liver is an important organ involved in the processes of digestion, excretion, detoxification and immunity. Liver diseases are common clinical diseases, such as viral hepatitis, cirrhosis and liver cancer, which are extremely harmful to human health. The liver-targeted drug delivery system is an important way to explore an effective treatment method for liver disease, as it enriches the drug at the site of the liver lesion to exert the curative effect, reducing the amount of drug and the number of drug administration. Liver cells are divided into hepatic parenchymal cells, Kupffer cells and endothelial cells, of which parenchymal cells are the main cells that make up the…
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How To Evaluate The Toxicology Of Nanoparticles
Nano-drug delivery systems are constantly exposed to complex physiological environments in vivo. The interaction between nano-materials, proteins and cells, their effects and possible toxicity is the key to evaluate and understand the compatibility and toxicity of nano-materials. Cell-based toxicity evaluation is the main method for the in vitro toxicity evaluation of nanometer drug delivery systems, including cell uptake and processing of nanomaterials, effects on cell signals, interference with membranes, effects on cell electron transfer beams, cytochemical factors and reactive oxygen species (ROS) production, intercellular interaction and intercellular transport, gene regulation, obvious toxic reactions, potential toxicity, and cell necrosis or apoptosis. Toxicology In Vitro Research Method Of Nano Drug Delivery System A variety of…
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How To Measure The Efficiency Of Drug Packaging?
The encapsulation efficiency is an important parameter of the nanodrugs delivery system and can be calculated by the following formula: Encapsulation efficiency (%) = Weight of the drug in nanoparticles / (Weight of the drug in nanoparticles +Weight of the drug in medium) X100% There are generally two methods for determining the drug encapsulation efficiency in a nanometer drug delivery system: 1) the free drug is separated from the nanocarrier and measured; 2) the free drug and the nanocarrier are not separated and measured directly. The first method requires the encapsulated drug to be stable and it should has no leakage during separation. The separation methods include dialysis, gel column chromatography, high speed centrifugation, centrifugal ultrafiltration and microcolumn centrifugation.…
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What Is Zeta Potential?
Zeta potential is a specialized term for kinetic potential in colloidal dispersions, also called electromotive potential (ζ-potential), which is used to characterize the surface potential of nanoparticles. Theoretically, zeta potential is the potential of the sliding surface in the interface bilayer relative to a point in the fluid far from the interface. In other words, zeta potential is the potential difference between the dispersion medium and the fluid-fixed layer attached to the dispersed particles. The potential is caused by the net charge in the area around the sliding plane and also depends on the position of the sliding plane. The higher the Zeta potential (positive or negative), the greater the…
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New Nanoparticle Technology For Controlling Size And Shape—MORPH
For decades, scientists have been studying how to make better use of nanoparticles in medicine. Nanoparticles are much smaller than normal cells and are more similar in size to proteins. This makes them good at interacting with biomolecules and transporting drug molecules attached to their surface through cell membranes. However, to date, only a few nanoparticle-based drugs have successfully entered the clinic. This is because there are challenges in controlling the size and shape of nanoparticles. However, although chemists have become skilled in manipulating molecules, it is even more challenging to achieve the same level of control at the nanometer level (just raising it to one level). In particular, highly heterogeneous structures are a natural target…
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What Is The Basic Principle Of Nano-Targeting
After administration of a common pharmaceutical preparation, it is usually freely distributed in the body and then taken up by cells and organs. Due to the existence of various biological barriers in the body, such as the blood-brain barrier and the blood-retinal barrier, only a small part of the drug reaches the target site. The targeted preparation can selectively concentrate the drug on the lesion by means of the nanocarrier, and the lesion can be a target tissue, a target organ, or a target cell or a target in the cell. According to the arrival location of the drug, the targeting can be divided into three levels: the first level refers…
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What Is Drug Controlled Release Nanotechnology
The positioning, timing and constant release of pharmaceutical preparations have always been the focus of pharmaceutics research. Special drug delivery systems are prepared by a variety of physical, chemical, and biological methods to control drug release behavior, release the drug at a fixed site of the organism, release it within a predetermined time, or release at a predetermined rate. Compared with common preparations, the controlled release drug delivery system has the advantages of less administration times, stable blood concentration, less drug irritation, and high bioavailability of the drug. Nanotechnology is used to prepare drug carriers by embedding, encapsulating, adsorbing or chemically binding the nanocarrier system. Specific carrier types include nanoparticles,…
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How To Modify The Surface Of Nanoparticles
After the material is micro-nanosized, especially in the nano-state, its size is between atoms, molecules and bulk materials, so it is called the fourth state of matter. As nanoparticles have many special properties, people have shown great enthusiasm for the research of nanomaterials. They have synthesized a variety of nano- and nano-composites with advanced functions and outstanding performance, which are widely used in various fields. The fine particle size, large specific surface area, insufficient atomic coordination and high surface energy of the nanoparticles make these surface atoms highly active, extremely unstable, and easy to agglomerate. This agglomerated secondary particles are difficult to exert their nano-effects, making the material less than…
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Nanoparticle Delivery Technology Crispr-Gold Helps Crispr Treatment of Autism
CRISPR is a repeating sequence in the prokaryotic genome. It is an immune weapon produced by the struggle between bacteria and viruses in the history of life evolution. Simply put, the virus can integrate its own genes into the bacterial genome and use the bacterial cell tools for its own the gene duplication service. In order to remove the foreign invading genes of the virus, Bacteria evolved the CRISPR-Cas9 system. With this system, bacteria can quietly remove the virus gene from its own chromosome, which is the unique immune system of bacteria. Microbiologists have mastered the immune function of bacteria with a variety of excised foreign virus genes. The more…
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Injectable Hydrogel
Hydrogels are gels in which water is the dispersion medium. The water-soluble polymer having a network cross-linking structure introduces a part of a hydrophobic group and a hydrophilic residue, and the hydrophilic residue is combined with a water molecule to connect the water molecule inside the network, and the hydrophobic residue expands with water. Hydrogels are well suited for a wide range of applications due to their high water content and the regulated mechanical properties. Studies have found that many hydrogel systems can form strong, tough and elastic covalently crosslinked hydrogel materials by covalent cross-linking methods, including light, temperature and pH-induced free radical processes. However, they may also Limited by…
