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Application of Protease-Responsive Nanocarriers In Near-Infrared Imaging
Cancer is one of the diseases that endanger human health. Successful diagnosis of early cancer is the key to treating and improving patient survival. Therefore, more and more research is focused on the development of dyes and drugs for cancer diagnosis and treatment. However, delivering these therapeutic (drug / dye) molecules to the site of a lesion in the body at an effective concentration is a challenge. With the research on nanotechnology, nanobiotechnology has played an important role in targeted drug application. This technology effectively improves the efficiency of therapeutic diagnostics by increasing the half-life of the molecule, maintaining effective concentrations at the target site, and reducing side effects. Recently,…
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How To Achieve Lung Targeting By Nano Drug Carrier
Due to the increasing environmental pollution and the harm of smoking, lung diseases have become an important factor affecting human health. One of the more serious diseases is lung cancer. Lung cancer is a malignant lung tumor that results from the uncontrolled growth of lung tissue cells. If left untreated, the tumor cells will metastasize to nearby tissues or elsewhere in the body. The most common primary malignant tumor of the lung is epithelial cancer, which can be roughly divided into small cell carcinoma (SCLC) and non-small cell carcinoma (NSCLC). The most common symptoms of lung cancer are cough (including hemoptysis), weight loss, shortness of breath, and chest pain. The majority (85%) of patients with lung…
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How Does The Nano-Drug Delivery System Achieve Lymphatic Targeting
Physiological characteristics of lymph The lymphatic system consists of lymphatic channels, lymphoid organs, and lymphoid tissues. Colorless and transparent lymph fluid flows in the lymph system. Lymphatic vessels include capillary lymphatic vessels, lymphatic vessels, and lymphatic ducts. Lymphatic organs include lymph nodes, thymus, and spleen. When blood flows through the capillaries, part of the liquid substance seeps into the interstitial space, forming interstitial fluid. Most are absorbed into the blood through the venous ends of the capillaries, and a small part of the water content and the interstitial fluid of macromolecules enter the capillary lymphatic vessels to become lymph. The lymph flows to the heart along the lymph vessels at…
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How The Liver-Targeted Nano-Drug Delivery System Is Realized
Physiological characteristics of the liver The liver is an important organ involved in the processes of digestion, excretion, detoxification and immunity. Liver diseases are common clinical diseases, such as viral hepatitis, cirrhosis and liver cancer, which are extremely harmful to human health. The liver-targeted drug delivery system is an important way to explore an effective treatment method for liver disease, as it enriches the drug at the site of the liver lesion to exert the curative effect, reducing the amount of drug and the number of drug administration. Liver cells are divided into hepatic parenchymal cells, Kupffer cells and endothelial cells, of which parenchymal cells are the main cells that make up the…
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How To Evaluate The Toxicology Of Nanoparticles
Nano-drug delivery systems are constantly exposed to complex physiological environments in vivo. The interaction between nano-materials, proteins and cells, their effects and possible toxicity is the key to evaluate and understand the compatibility and toxicity of nano-materials. Cell-based toxicity evaluation is the main method for the in vitro toxicity evaluation of nanometer drug delivery systems, including cell uptake and processing of nanomaterials, effects on cell signals, interference with membranes, effects on cell electron transfer beams, cytochemical factors and reactive oxygen species (ROS) production, intercellular interaction and intercellular transport, gene regulation, obvious toxic reactions, potential toxicity, and cell necrosis or apoptosis. Toxicology In Vitro Research Method Of Nano Drug Delivery System A variety of…
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How To Measure The Efficiency Of Drug Packaging?
The encapsulation efficiency is an important parameter of the nanodrugs delivery system and can be calculated by the following formula: Encapsulation efficiency (%) = Weight of the drug in nanoparticles / (Weight of the drug in nanoparticles +Weight of the drug in medium) X100% There are generally two methods for determining the drug encapsulation efficiency in a nanometer drug delivery system: 1) the free drug is separated from the nanocarrier and measured; 2) the free drug and the nanocarrier are not separated and measured directly. The first method requires the encapsulated drug to be stable and it should has no leakage during separation. The separation methods include dialysis, gel column chromatography, high speed centrifugation, centrifugal ultrafiltration and microcolumn centrifugation.…
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What Is Zeta Potential?
Zeta potential is a specialized term for kinetic potential in colloidal dispersions, also called electromotive potential (ζ-potential), which is used to characterize the surface potential of nanoparticles. Theoretically, zeta potential is the potential of the sliding surface in the interface bilayer relative to a point in the fluid far from the interface. In other words, zeta potential is the potential difference between the dispersion medium and the fluid-fixed layer attached to the dispersed particles. The potential is caused by the net charge in the area around the sliding plane and also depends on the position of the sliding plane. The higher the Zeta potential (positive or negative), the greater the…
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New Nanoparticle Technology For Controlling Size And Shape—MORPH
For decades, scientists have been studying how to make better use of nanoparticles in medicine. Nanoparticles are much smaller than normal cells and are more similar in size to proteins. This makes them good at interacting with biomolecules and transporting drug molecules attached to their surface through cell membranes. However, to date, only a few nanoparticle-based drugs have successfully entered the clinic. This is because there are challenges in controlling the size and shape of nanoparticles. However, although chemists have become skilled in manipulating molecules, it is even more challenging to achieve the same level of control at the nanometer level (just raising it to one level). In particular, highly heterogeneous structures are a natural target…
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What Is The Basic Principle Of Nano-Targeting
After administration of a common pharmaceutical preparation, it is usually freely distributed in the body and then taken up by cells and organs. Due to the existence of various biological barriers in the body, such as the blood-brain barrier and the blood-retinal barrier, only a small part of the drug reaches the target site. The targeted preparation can selectively concentrate the drug on the lesion by means of the nanocarrier, and the lesion can be a target tissue, a target organ, or a target cell or a target in the cell. According to the arrival location of the drug, the targeting can be divided into three levels: the first level refers…
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What Is Drug Controlled Release Nanotechnology
The positioning, timing and constant release of pharmaceutical preparations have always been the focus of pharmaceutics research. Special drug delivery systems are prepared by a variety of physical, chemical, and biological methods to control drug release behavior, release the drug at a fixed site of the organism, release it within a predetermined time, or release at a predetermined rate. Compared with common preparations, the controlled release drug delivery system has the advantages of less administration times, stable blood concentration, less drug irritation, and high bioavailability of the drug. Nanotechnology is used to prepare drug carriers by embedding, encapsulating, adsorbing or chemically binding the nanocarrier system. Specific carrier types include nanoparticles,…
