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How To Modify The Surface Of Nanoparticles
After the material is micro-nanosized, especially in the nano-state, its size is between atoms, molecules and bulk materials, so it is called the fourth state of matter. As nanoparticles have many special properties, people have shown great enthusiasm for the research of nanomaterials. They have synthesized a variety of nano- and nano-composites with advanced functions and outstanding performance, which are widely used in various fields. The fine particle size, large specific surface area, insufficient atomic coordination and high surface energy of the nanoparticles make these surface atoms highly active, extremely unstable, and easy to agglomerate. This agglomerated secondary particles are difficult to exert their nano-effects, making the material less than…
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Nanoparticle Delivery Technology Crispr-Gold Helps Crispr Treatment of Autism
CRISPR is a repeating sequence in the prokaryotic genome. It is an immune weapon produced by the struggle between bacteria and viruses in the history of life evolution. Simply put, the virus can integrate its own genes into the bacterial genome and use the bacterial cell tools for its own the gene duplication service. In order to remove the foreign invading genes of the virus, Bacteria evolved the CRISPR-Cas9 system. With this system, bacteria can quietly remove the virus gene from its own chromosome, which is the unique immune system of bacteria. Microbiologists have mastered the immune function of bacteria with a variety of excised foreign virus genes. The more…
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Injectable Hydrogel
Hydrogels are gels in which water is the dispersion medium. The water-soluble polymer having a network cross-linking structure introduces a part of a hydrophobic group and a hydrophilic residue, and the hydrophilic residue is combined with a water molecule to connect the water molecule inside the network, and the hydrophobic residue expands with water. Hydrogels are well suited for a wide range of applications due to their high water content and the regulated mechanical properties. Studies have found that many hydrogel systems can form strong, tough and elastic covalently crosslinked hydrogel materials by covalent cross-linking methods, including light, temperature and pH-induced free radical processes. However, they may also Limited by…
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Application of Iron Oxide Nanoparticles in Tumor Imaging and Treatment
Magnetic nanoparticles have received great attention in various fields due to their unique physicochemical properties and wide application potential.In the past decade, the synthesis and application of magnetic nanoparticles from the bottom up has been a hot topic in the field of chemistry, chemical engineering, materials science and biomedicine. High-quality magnetic nanoparticles can be synthesized by chemical methods such as coprecipitation, high temperature thermal decomposition, and sol-gel methods. Compared to the top-down synthesis method, the bottom-up synthesis method can synthesize nanoparticles with uniform particle size and can be widely used in various fields: data storage, catalysts, biological separation and biosensing. A typical magnetic nanoparticle is synthesized by a bottom-up method comprising…
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Research Progress of Mesoporous Silica in Drug Delivery Systems
In recent years, the development of nanotechnology has brought about the dawn of overcoming many problems of traditional clinical drugs such as low solubility, weak selectivity, biodistribution and poor pharmacokinetics. Currently, a variety of nanomaterials such as silica, liposomes, carbon materials, layered hydroxides, and polymers have been reported as carriers for drug delivery. However, these new drug delivery systems still have many defects. For example, direct mixing of the silica sol and the drug results in heterogeneous dispersion of the drug, thereby causing the drug release rate to be affected by the sample batch. Liposomal carriers are less stable and are easily cleared by the reticuloendothelial system, resulting in fewer…
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Nanoparticle Drug Delivery De-immunization Study
The human immune system can recognize and destroy foreign objects. In addition to bacteria and viruses, drug-delivering nanoparticles, implanted pacemakers, and artificial joints, which are also foreign, also trigger an immune response that causes drug failure, rejection, or inflammation. To this end, scientists at the University of Pennsylvania have developed a new method of attaching protein “passports” to these therapeutic devices so that they can pass through the body’s defense system. The body will reject the invading foreign objects without discrimination, which is caused by the body’s natural immune system. This process involves a variety of cells, such as macrophages, which can detect, swallow and destroy invaders; serum proteins will…
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Method for Isolation And Identification of Extracellular Vesicles
Extracellular vesicles (EVs) are a general term for various vesicles with a lipid bilayer membrane structure that are released under resting or stress conditions. The diameter of the vesicles ranges from tens of nanometers to several micrometers. Studies have found that extracellular bodies are involved in a variety of physiological processes in the body and are associated with a variety of pathological processes such as infectious diseases and inflammation, nervous system diseases and cancer. Therefore, extracellular vesicles can be used to monitor disease progression, therapeutic response, and the like. At the same time, because of their ability to deliver bioactive substances, it can also be used as a new nano…
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How Can Phage Display Peptides Be Used in Nano-Drug Carriers
Nanoparticles have received extensive attention as drug carriers in the diagnosis of specific diseases, the detection and monitoring of therapeutic agents, and targeted therapies. The primary strategy for targeting drug carriers is to achieve targeting by utilizing specific recognition capabilities such as antibodies and antigens, ligands and receptors. This type of targeting is often referred to as “active targeting” by functionalizing the surface of the nanoparticle to achieve targeted behavior. Currently, researchers have developed new nanoparticle ligand drug carriers using phage display technology. The phage display technology is to clone a polypeptide or a protein coding gene or target gene fragment into a proper position of a phage coat protein…
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How to Achieve Brain Targeting in Nano Drug Delivery System
The blood-brain barrier (BBB) is a barrier system that exists between the blood system and the brain tissue, and is mainly composed of polarized intercellular tight junctions of polarized brain capillary endothelial cells (BCECs). It maintains a relatively stable internal environment for brain tissue, guarantees the normal physiological function of the central nervous system (CNS), and transports nutrients to the brain; but at the same time, its existence also hinders the drug of diagnosis and treatment into the brain. About 98% of small molecule drugs and almost 100% of macromolecular drugs, including proteins, peptides and gene drugs, cannot be directly delivered into the brain by peripheral administration, which is a…
