-
Application of Iron Oxide Nanoparticles in Tumor Imaging and Treatment
Magnetic nanoparticles have received great attention in various fields due to their unique physicochemical properties and wide application potential.In the past decade, the synthesis and application of magnetic nanoparticles from the bottom up has been a hot topic in the field of chemistry, chemical engineering, materials science and biomedicine. High-quality magnetic nanoparticles can be synthesized by chemical methods such as coprecipitation, high temperature thermal decomposition, and sol-gel methods. Compared to the top-down synthesis method, the bottom-up synthesis method can synthesize nanoparticles with uniform particle size and can be widely used in various fields: data storage, catalysts, biological separation and biosensing. A typical magnetic nanoparticle is synthesized by a bottom-up method comprising…
-
Research Progress of Mesoporous Silica in Drug Delivery Systems
In recent years, the development of nanotechnology has brought about the dawn of overcoming many problems of traditional clinical drugs such as low solubility, weak selectivity, biodistribution and poor pharmacokinetics. Currently, a variety of nanomaterials such as silica, liposomes, carbon materials, layered hydroxides, and polymers have been reported as carriers for drug delivery. However, these new drug delivery systems still have many defects. For example, direct mixing of the silica sol and the drug results in heterogeneous dispersion of the drug, thereby causing the drug release rate to be affected by the sample batch. Liposomal carriers are less stable and are easily cleared by the reticuloendothelial system, resulting in fewer…
-
Nanoparticle Drug Delivery De-immunization Study
The human immune system can recognize and destroy foreign objects. In addition to bacteria and viruses, drug-delivering nanoparticles, implanted pacemakers, and artificial joints, which are also foreign, also trigger an immune response that causes drug failure, rejection, or inflammation. To this end, scientists at the University of Pennsylvania have developed a new method of attaching protein “passports” to these therapeutic devices so that they can pass through the body’s defense system. The body will reject the invading foreign objects without discrimination, which is caused by the body’s natural immune system. This process involves a variety of cells, such as macrophages, which can detect, swallow and destroy invaders; serum proteins will…
-
Method for Isolation And Identification of Extracellular Vesicles
Extracellular vesicles (EVs) are a general term for various vesicles with a lipid bilayer membrane structure that are released under resting or stress conditions. The diameter of the vesicles ranges from tens of nanometers to several micrometers. Studies have found that extracellular bodies are involved in a variety of physiological processes in the body and are associated with a variety of pathological processes such as infectious diseases and inflammation, nervous system diseases and cancer. Therefore, extracellular vesicles can be used to monitor disease progression, therapeutic response, and the like. At the same time, because of their ability to deliver bioactive substances, it can also be used as a new nano…
-
How Can Phage Display Peptides Be Used in Nano-Drug Carriers
Nanoparticles have received extensive attention as drug carriers in the diagnosis of specific diseases, the detection and monitoring of therapeutic agents, and targeted therapies. The primary strategy for targeting drug carriers is to achieve targeting by utilizing specific recognition capabilities such as antibodies and antigens, ligands and receptors. This type of targeting is often referred to as “active targeting” by functionalizing the surface of the nanoparticle to achieve targeted behavior. Currently, researchers have developed new nanoparticle ligand drug carriers using phage display technology. The phage display technology is to clone a polypeptide or a protein coding gene or target gene fragment into a proper position of a phage coat protein…
-
How to Achieve Brain Targeting in Nano Drug Delivery System
The blood-brain barrier (BBB) is a barrier system that exists between the blood system and the brain tissue, and is mainly composed of polarized intercellular tight junctions of polarized brain capillary endothelial cells (BCECs). It maintains a relatively stable internal environment for brain tissue, guarantees the normal physiological function of the central nervous system (CNS), and transports nutrients to the brain; but at the same time, its existence also hinders the drug of diagnosis and treatment into the brain. About 98% of small molecule drugs and almost 100% of macromolecular drugs, including proteins, peptides and gene drugs, cannot be directly delivered into the brain by peripheral administration, which is a…
