-
How to Achieve Brain Targeting in Nano Drug Delivery System
The blood-brain barrier (BBB) is a barrier system that exists between the blood system and the brain tissue, and is mainly composed of polarized intercellular tight junctions of polarized brain capillary endothelial cells (BCECs). It maintains a relatively stable internal environment for brain tissue, guarantees the normal physiological function of the central nervous system (CNS), and transports nutrients to the brain; but at the same time, its existence also hinders the drug of diagnosis and treatment into the brain. About 98% of small molecule drugs and almost 100% of macromolecular drugs, including proteins, peptides and gene drugs, cannot be directly delivered into the brain by peripheral administration, which is a…
