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Application of Carrageenan Hydrogel in Biomedical Field
Hydrogel is a three-dimensional network of hydrophilic polymers that swells in water without dissolving. Because the polymer contains a large number of hydrophilic groups, the hydrogel can absorb and lock a large amount of water. After absorbing water, the hydrogel network can maintain its original shape without being destroyed. Hydrogels are widely used in tissue engineering, drug delivery, biosensing, etc. due to their simple preparation, strong tunability of mechanical properties, good biocompatibility, and elasticity and softness that are very similar to most tissues and extracellular matrices of the human body. The field is developing rapidly. Depending on the source from which the hydrogel is prepared, hydrogels can be divided into…
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Micelle vs Liposome
Micelles refer to molecularly ordered aggregates that begin to form in large quantities after the surfactant concentration reaches a certain value in an aqueous solution. In micelles, the hydrophobic groups of surfactant molecules aggregate to form the core of the micelle, and the hydrophilic polar groups form the outer layer of the micelle. Liposomes are an artificial membrane. In the water, the hydrophilic head of the phospholipid molecule is inserted into the water, and the hydrophobic tail of the liposome extends into the air. After stirring, a spherical liposome with a double layer of lipid molecules is formed, with a diameter ranging from 25 to 1000 nm. Micelles and liposomes…
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Application of 3D Printing Bioinks Tissue Repair and Regenerative Medicine
Introduction to 3D Printing In the 1980s, American engineer Charles Hull developed rapid prototyping technology by combining points and surfaces and then using light reinforcement. After numerous failures, he finally invented stereolithography technology. Based on this technology, the world’s The first 3D printer came into being. By the end of the 1990s, researchers combined 3D printing technology with the field of medical care to create substitutes for human organs for adjuvant treatment, which created a new field – 3D bioprinting. 3D bioprinting is a novel technology that can create structures that can combine living cells or biomaterials and control cell proliferation, differentiation, and migration on this structure. At present, 3D…
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Lipid Nanomedicine Delivery In Vivo
In the past few decades, the advent of lipid-based nano-delivery systems has brought research in the field of nanomedicines to new heights. Nanocarriers can encapsulate different types of drug molecules and have the advantages of improving drug solubility, extending circulation, achieving sustained and controlled drug release and targeted delivery. Lipids are important components of organisms, including fats, phospholipids, sterols, etc. Among them, phospholipids and sterols are the main components of biological membranes. Compared with other nanoformulations, lipid-based nanocarriers have good biocompatibility and complete biodegradability, low carrier toxicity and immunogenicity, and have great potential in clinical practice for the treatment of various diseases. Most of the nanomedicines currently on the market are…
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Introduction to Drug Delivery System Based on Apoptotic Body
Extracellular vesicles are a series of membrane-structured vesicles released by cells, including exosomes, microvesicles, and apoptotic bodies. Extracellular vesicles are composed of various lipids and membrane proteins, some of which special membrane proteins help target specific tissues and cells, while others ensure that non-specific interactions are minimized, these physiological properties endow Thanks to their excellent biocompatibility and ability to target lesions, extracellular vesicles can be widely used in research in the field of drug delivery. Compared with exosomes and microvesicles produced by living cells, apoptotic bodies derived from apoptotic cells have a higher production efficiency. Apoptosis is a natural process in which cells actively package biomolecules into vesicles. Based on…
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Natural Nanocarriers for Delivery Protein Drug
Protein accounts for 18-20% of the total mass of the human body and is the main carrier of human life activity. Protein has a range of complex functions in the organism, and many human diseases are closely related to the functional regulation of protein. For example, Parkinson’s disease (PD). It is understood that protein-stable imbalance disorders associated with mitochondria are important factors that lead to PD disease. Recent studies have shown that protein / sulfur dioxide heterogeneizes can reduce endoplasmic reticulum stress and regulate unfolded protein stress signal pathway changes, which can provide neuroprotective effects in cell PD models, effectively improving Parkinson’s syndrome epithetics. Cancer is another disease closely related…
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What is a Micro Needle Array Based on Nanomaterials?
Micro needle (MN) is a micro needle-shaped structure, the length of 100 ~ 1000μm, the bottom diameter of several hundred micrometers, the tip diameter is less than a few dozen micrometer, usually in the form of micro- needle array sticker, can penetrate the skin surface cortex to form micro-porous tubes, without touching the nerve endings within the cortex causing pain. At present, researchers generally use silicon, metal, polymers and other materials to prepare micro needles through traditional microelectronic mechanical systems (MEMS) processes and new processing technologies. Depending on the way of action, the micro needle can be divided into solid, coated, empty, soluble and hydrogel micro needles, widely used in…
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How to Prepare Sodium Alginate Microspheres with Controllable Particle Size
Sodium alginate is a sodium salt of polyanionic alginic acid. It is a natural high molecular polysaccharide polymer extracted from natural brown algae. It has the advantages of wide source, low price, good biocompatibility, and degradability. Contains multiple hydroxyl and carboxyl functional groups, so it can react with a variety of divalent or trivalent cations to form hydrogels, and is widely used in biomedical fields such as cell engineering, drug sustained release, and medical dressings. When sodium alginate microspheres are applied to the fields of drug loading, controlled release, and interventional therapy, the control of particle size and morphology of the microspheres is particularly important. For large-sized microspheres ranging from…
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What is a Nano-Drug Delivery System of Natural Polysaccharides
Nano drug delivery system refers to the drug delivery system composed of natural or synthetic polymer materials with a particle size of 1-1000 nm. Nano-drug delivery carriers have the characteristics of biodegradability, low drug toxicity, slow-controlled release and targeted drug delivery, and are widely favored by researchers in the field of medicine. Metabolism, which can play a sustained release effect; enhance the stability of the loaded drug and improve its bioavailability in vivo; the particle size of the delivery system is smaller than the capillary channel, and can be passively targeted to tumor tissue through the high permeability and long retention (EPR) effect; After the carrier is specially modified, it…
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Carrageenans as a Versatile Tool in Drug Delivery
Drug delivery is the process of administering pharmaceutical substances to targeted areas in the body. It plays a vital role in the effective treatment of various diseases. However, drug delivery is often challenged by the body’s natural defenses, such as the gastrointestinal tract and the immune system, which can prevent the drug from reaching its intended target. Carrageenans, a family of sulfated polysaccharides derived from red seaweed, have been shown to be an effective tool in drug delivery due to their unique properties. Carrageenans are a natural, renewable, and biocompatible source of polymer that can be easily extracted from red seaweed. They are structurally diverse and have a range of…
