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Natural Nanocarriers for Delivery Protein Drug
Protein accounts for 18-20% of the total mass of the human body and is the main carrier of human life activity. Protein has a range of complex functions in the organism, and many human diseases are closely related to the functional regulation of protein. For example, Parkinson’s disease (PD). It is understood that protein-stable imbalance disorders associated with mitochondria are important factors that lead to PD disease. Recent studies have shown that protein / sulfur dioxide heterogeneizes can reduce endoplasmic reticulum stress and regulate unfolded protein stress signal pathway changes, which can provide neuroprotective effects in cell PD models, effectively improving Parkinson’s syndrome epithetics. Cancer is another disease closely related…
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What is a Micro Needle Array Based on Nanomaterials?
Micro needle (MN) is a micro needle-shaped structure, the length of 100 ~ 1000μm, the bottom diameter of several hundred micrometers, the tip diameter is less than a few dozen micrometer, usually in the form of micro- needle array sticker, can penetrate the skin surface cortex to form micro-porous tubes, without touching the nerve endings within the cortex causing pain. At present, researchers generally use silicon, metal, polymers and other materials to prepare micro needles through traditional microelectronic mechanical systems (MEMS) processes and new processing technologies. Depending on the way of action, the micro needle can be divided into solid, coated, empty, soluble and hydrogel micro needles, widely used in…
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How to Prepare Sodium Alginate Microspheres with Controllable Particle Size
Sodium alginate is a sodium salt of polyanionic alginic acid. It is a natural high molecular polysaccharide polymer extracted from natural brown algae. It has the advantages of wide source, low price, good biocompatibility, and degradability. Contains multiple hydroxyl and carboxyl functional groups, so it can react with a variety of divalent or trivalent cations to form hydrogels, and is widely used in biomedical fields such as cell engineering, drug sustained release, and medical dressings. When sodium alginate microspheres are applied to the fields of drug loading, controlled release, and interventional therapy, the control of particle size and morphology of the microspheres is particularly important. For large-sized microspheres ranging from…
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What is a Nano-Drug Delivery System of Natural Polysaccharides
Nano drug delivery system refers to the drug delivery system composed of natural or synthetic polymer materials with a particle size of 1-1000 nm. Nano-drug delivery carriers have the characteristics of biodegradability, low drug toxicity, slow-controlled release and targeted drug delivery, and are widely favored by researchers in the field of medicine. Metabolism, which can play a sustained release effect; enhance the stability of the loaded drug and improve its bioavailability in vivo; the particle size of the delivery system is smaller than the capillary channel, and can be passively targeted to tumor tissue through the high permeability and long retention (EPR) effect; After the carrier is specially modified, it…
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Carrageenans as a Versatile Tool in Drug Delivery
Drug delivery is the process of administering pharmaceutical substances to targeted areas in the body. It plays a vital role in the effective treatment of various diseases. However, drug delivery is often challenged by the body’s natural defenses, such as the gastrointestinal tract and the immune system, which can prevent the drug from reaching its intended target. Carrageenans, a family of sulfated polysaccharides derived from red seaweed, have been shown to be an effective tool in drug delivery due to their unique properties. Carrageenans are a natural, renewable, and biocompatible source of polymer that can be easily extracted from red seaweed. They are structurally diverse and have a range of…
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Brief Introduction of Xanthan Gum
Xanthan gum, also known as yellow gum, is white or light yellow powder. In 1952, it was isolated and extracted from the pathogenic strain of Xanthomonas campestris by the northern laboratory of the United States. After in-depth research, it was found that xanthan gum has excellent rheological properties and can partially or completely replace other gloea. Since then, xanthan gum has been extensively studied. Xanthan gum was discovered in 1954, and it has been industrialized for less than 70 years since 1964. It has become one of the most widely used biological gums in the world, and has been used in food, petroleum, and pharmaceutical fields. Xanthan Gum Structure Xanthan…
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Research Progress of Pectin and Its Medical Application
Pectin is a hydrophilic vegetable gum. Widely present in the fruits, roots, stems and leaves of higher plants, it is a component of the cell wall. The pectin content of different plants or different parts of the same plant varies greatly. So far, only a few plants with high pectin content have been found and used as raw materials for industrial production, mainly citrus peels, sunflower trays, and sugar beets. Pectin is the general term for protopectin, pectin and pectic acid. Protopectin is insoluble in water and only exists in the cell wall; pectin is soluble in water and exists in the cell juice; pectin acid is slightly soluble in…
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Gene Carrier Based on Nanomaterials
Gene therapy refers to the introduction of normal foreign genes into target cells to compensate or correct diseases caused by gene defects or abnormalities, so as to achieve the purpose of treatment. Naked DNA usually requires physical methods to enter tissues or cells, and DNA is easily digested and degraded by various enzymes in tissues or cells, resulting in a very low expression level of the encoded protein, which affects the effect of gene therapy. Therefore, the development of gene carriers with low toxicity and high efficiency is one of the urgent problems to be solved in gene therapy. Gene vectors are generally divided into two categories: viral vectors and…
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Research Progress of PROTAC in the Treatment of Malignant Tumors
Malignant tumors are a major global public health problem, the leading cause of death in developing countries and the second leading cause of death in developed countries. Traditional treatment methods such as surgical resection, radiotherapy and chemotherapy have serious side effects on the body. Tumor immunotherapies such as small molecule inhibitors and monoclonal antibodies act on the body’s immune system to remove tumor cells and reduce the immunosuppressive signals caused by tumor cells, and achieve good clinical results. However, tumor cells are prone to gene mutations to escape immune surveillance, and small molecule inhibitors are prone to drug resistance and off-target effects. Monoclonal antibodies have large molecular weights, are difficult…
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A Review of Proteolytic Targeting Chimeras
The concept of proteolytic targeting chimera (PROTAC) was first proposed by Crews and Deshaies laboratory in 2001, the team successfully achieved the degradation of methionyl aminopeptidase 2 (MetAp-2) by PROTAC method. Since then, PROTACs targeting androgen receptor (AR) and estrogen receptor (ER) have appeared one after another. In 2004, a PROTAC molecule that recruited the tumor suppressor protein VHL through a polypeptide fragment on HIF1-α showed a greater improvement in membrane permeability and could also exist stably in cells. However, these peptide-based PROTAC molecules were not ready for drug preparation. Until 2008, when the first small-molecule E3 ubiquitinase ligand-based PROTAC came out, marking the beginning of small-molecule PROTAC research, and…
