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Liposomes as Carriers of Antitumor Drug
In recent years, the incidence of tumors has become higher and the tumor patients seem to be younger, which has seriously affected people’s health and quality of life. According to statistics, the number of newly diagnosed cancer patients in the world in 2007 has reached 12 million, and as many as 7 million people die from cancer worldwide each year. The current effective method is chemotherapy. Compared with normal tissues, tumor tissue has increased vascular endothelial cell space, thin blood vessel walls, and increased vascular permeability, and it also lacks of lymphatic vessels in tumor tissue, which reduces the discharge of metabolites. Normal tissues have small capillary endothelial membrane pores.…
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In Vivo Characteristics of Antitumor Drug Liposomes
Anti-tumor drug liposomes need to be studied in vivo during the development process, which includes examination of liposome pharmacokinetics, clinical efficacy and in vivo safety. Pharmacokinetics Liposomes have a greater influence on the pharmacokinetic parameters of drug-loaded drugs, which are characterized by increased AUC(area under the curve, it shows drug’s bioavailabilit), extended half-life period, decreased clearance, decreased volume of distribution, and changes in tissue distribution. The pharmacological changes can be explained and proven from the anatomical characteristics of tumor sites, structural characteristics of liposomes, non-clinical studies and clinical studies. The targeting of liposomes is divided into passive targeting, physicochemical targeting and active targeting. These targeting effects make the pharmacokinetic behavior of liposome…
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How Integrin-Targeted Plaga-Chitosan Nanoparticles Are Used In Tumor Treatment
Since most chemotherapeutic drugs are toxic to normal cells, it is an important goal for cancer drug carrier development to achieve the appropriate concentration of therapeutic drugs at the location of cancer cells while reducing the exposure of normal cells to chemotherapeutic drugs. Chemotherapy is non-specific for normal cytotoxicity, mainly dose-dependent toxicity. Studies have found that targeted drug delivery systems show a higher affinity for tumor cells. Therefore, targeted nanoparticle-based drug delivery is a promising method to overcome this challenge. In lung cancer clinical studies, overexpressing receptors on cancer cell surfaces are often used as targets for therapeutic and ligand / antibody-modified nanodrug delivery vehicles. Previous studies have shown that…
