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In Vivo Characteristics of Antitumor Drug Liposomes
Anti-tumor drug liposomes need to be studied in vivo during the development process, which includes examination of liposome pharmacokinetics, clinical efficacy and in vivo safety. Pharmacokinetics Liposomes have a greater influence on the pharmacokinetic parameters of drug-loaded drugs, which are characterized by increased AUC(area under the curve, it shows drug’s bioavailabilit), extended half-life period, decreased clearance, decreased volume of distribution, and changes in tissue distribution. The pharmacological changes can be explained and proven from the anatomical characteristics of tumor sites, structural characteristics of liposomes, non-clinical studies and clinical studies. The targeting of liposomes is divided into passive targeting, physicochemical targeting and active targeting. These targeting effects make the pharmacokinetic behavior of liposome…
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Application Prospects of Targeted Nano Drug Delivery System
Targeted drugs were proposed by German scientist and Nobel Prize winner Ehrlich in 1906 and have a history of more than 100 years. Until the late 1970s, with the advancement of molecular biology, cell biology, and materials science, targeted formulations developed rapidly, and products began to be marketed. The nano drug delivery system is distributed in specific organs, tissues, cells, and even intracellular structures in the body through passive targeting, active targeting, physical and chemical targeting, etc., and changes the distribution of prototype drugs in vivo. With the leapfrog development of life sciences, human understanding of disease pathogenesis and drug action mechanisms has transitioned from a macroscopic overall level to…
