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New Research Develops a New X-ray Responsive Degradation Nano-drug Carrier System
Chemotherapy is a commonly used clinical treatment for tumors, but single-molecule chemotherapeutics have low bioavailability and large side effects, which could be a significant burden to patients and their families. Nanotechnology prepares single-molecule chemotherapeutic drugs into nanometer drugs, which can achieve tumor targeting and controllable release of chemotherapeutic drugs, thereby improving the therapeutic effect and reducing toxic and side effects, which is conducive to achieving high-efficiency and low-toxicity chemotherapy. Mesoporous silica nanomaterials have the advantages of simple synthesis, controllable structure, good chemical tailoring and biocompatibility, and are a nano-medicine carrier platform with good clinical application prospects. According to the characteristics of micro-acid, hypoxia and high redox in the tumor microenvironment, researchers have developed a…
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Research Progress of Mesoporous Silica in Drug Delivery Systems
In recent years, the development of nanotechnology has brought about the dawn of overcoming many problems of traditional clinical drugs such as low solubility, weak selectivity, biodistribution and poor pharmacokinetics. Currently, a variety of nanomaterials such as silica, liposomes, carbon materials, layered hydroxides, and polymers have been reported as carriers for drug delivery. However, these new drug delivery systems still have many defects. For example, direct mixing of the silica sol and the drug results in heterogeneous dispersion of the drug, thereby causing the drug release rate to be affected by the sample batch. Liposomal carriers are less stable and are easily cleared by the reticuloendothelial system, resulting in fewer…
