Investigation of Efficacy of Anti-Aging Liposomal Intimate Gel: An In Vivo Long-Term Study

Nesic, I; Savic, V; Kolarevic, A

Abstract

Liposomes have been used as universal carriers for decades, encapsulating many compounds with different cosmetic effects in order to achieve the quality, safety and efficacy of functional cosmetic products. In the present study, the efficacy of the application of the commercial liposome gel (SOPHY Anti-Aging Liposomal Intimate Gel), containing L-arginine, white curcuma extract, hyaluronic acid, lactic acid and vitamin E (previously shown to have various positive effects on the skin) as encapsulated cosmetic active ingredients, was examined in vivo on healthy volunteers. During a long-term 28-day study, biophysical skin parameters (skin humidity, TEWL, EI and pH) were monitored. As a result, an increase in skin hydration, decrease in TEWL, and a slight decrease in EI and skin pH were observed. Thus, the examined cosmetic product has shown a positive effect on skin hydration, contributing to the renewal of skin barrier, also having the anti-irritating effects.

Keywords: liposomal intimate gel; efficacy; in vivo study; biophysical skin parameters

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Liposomes for Cosmetics

Anti-aging liposomes represent a revolutionary advancement in skincare, offering a potent and targeted approach to combating the signs of aging. Liposomes, spherical vesicles composed of phospholipid bilayers, are capable of encapsulating a variety of active ingredients such as antioxidants, peptides, vitamins, and hyaluronic acid. These ingredients are crucial for skin rejuvenation and repair. The biocompatibility of liposomes ensures that they can seamlessly integrate with the skin’s natural barrier, facilitating deeper penetration of these active compounds into the dermis where they can exert their maximum effect. This targeted delivery system enhances the stability and bioavailability of anti-aging ingredients, ensuring they reach the cells where they are needed most, effectively reducing wrinkles, fine lines, and other signs of aging. Moreover, the controlled release properties of liposomes allow for a sustained release of active ingredients, providing long-lasting benefits and continuous nourishment to the skin. By protecting the encapsulated ingredients from degradation, liposomes also enhance the efficacy of the anti-aging formulations. Overall, anti-aging liposomes offer a sophisticated, efficient, and highly effective method for delivering rejuvenating compounds to the skin, significantly improving the appearance and health of aging skin.