The Most Cited Literature on Block Copolymer Micelles

Block copolymer micelles are generally formed by the self-assembly of either amphiphilic or oppositely charged copolymers in aqueous medium. In this article, the editor summarizes the most cited research results that scientists have made on block copolymer micelles, and hope you can find what you need.

1. What are Block Copolymer Micelles?

Block copolymer micelles are generally formed by the self-assembly of either amphiphilic or oppositely charged copolymers in aqueous medium. The hydrophilic and hydrophobic blocks form the corona and the core of the micelles, respectively. The presence of a nonionic water-soluble shell as well as the scale (10-100 nm) of polymeric micelles are expected to restrict their uptake by the mononuclear phagocyte system and allow for passive targeting of cancerous or inflamed tissues through the enhanced permeation and retention effect.

From: Block copolymer micelles: preparation, characterization and application in drug delivery.—Cited by 1479.

2. Block Copolymer Micelles in Nanomedicine Applications

Polymeric micelles are demonstrating high potential as nanocarriers capable of controlling the distribution and function of loaded bioactive agents in the body, effectively overcoming biological barriers. This review focuses on polymeric micelles assembled through multimolecular interactions between block copolymers and the loaded drugs, proteins, or nucleic acids as translationable nanomedicines.

From: Block Copolymer Micelles in Nanomedicine Applications.—Cited by 310.

2. Block Copolymer Micelles for Drug Delivery

Recently, colloidal carrier systems have been receiving much attention in the field of drug targeting because of their high loading capacity for drugs as well as their unique disposition characteristics in the body. This paper highlights the utility of polymeric micelles formed through the multimolecular assembly of block copolymers as novel core–shell typed colloidal carriers for drug and gene targeting.

From: Block copolymer micelles for drug delivery: Design, characterization and biological significance.—Cited by 4084.

3. Block Copolymer Micelles as Long-circulating Drug Vehicles

The development of block copolymer micelles as long-circulating drug vehicles is described. As well, a recent fundamental study of block copolymer micelles, where much insight into their structures and properties has been realized, is briefly summarized in order to shed light on their properties in vivo. There is emphasis on block copolymer micelles having poly(ethylene oxide) as the hydrophilic block and poly(l-amino acid) as the hydrophobic block, with some discussion on the properties of poly(ethylene oxide).

From: Block copolymer micelles as long-circulating drug vehicles.—Cited by 946.

4. Cylindrical Block Copolymer Micelles and Co-Micelles of Controlled Length and Architecture

Block copolymers consist of two or more chemically different polymers connected by covalent linkages. In solution, repulsion between the blocks leads to a variety of morphologies, which are thermodynamically driven. Polyferrocenyldimethylsilane block copolymers show an unusual propensity to forming cylindrical micelles in solution. The micelle structure grows epitaxially through the addition of more polymer, producing micelles with a narrow size dispersity, in a process analogous to the growth of living polymer.

From: Cylindrical Block Copolymer Micelles and Co-Micelles of Controlled Length and Architecture.—Cited by 879.

5. Cross-linked Block Copolymer Micelles

Supramolecular self assembly techniques have provided a versatile means by which to selectively assemble polymer molecules into well-defined three dimensional core–shell nanostructures. The covalent stabilisation and tailoring of these dynamic nanostructures can be achieved using a range of chemistries within the assembly to afford robust functional nanoparticles.

From: Cross-linked block copolymer micelles: functional nanostructures of great potential and versatility.—Cited by 886.

References

1. Gaucher, Geneviève, et al. Block copolymer micelles: preparation, characterization and application in drug delivery. Journal of controlled release,2005, 1-3: 169-188.
2. Cabral, Horacio, et al. Block copolymer micelles in nanomedicine applications.Chemical reviews. 2018, 14: 6844-6892.
3. Kataoka, et al. Block copolymer micelles for drug delivery: design, characterization and biological significance.Advanced drug delivery reviews, 2012, 64: 37-48.
4. Kwon, et al. Block copolymer micelles as long-circulating drug vehicles.Advanced drug delivery reviews, 1995, 2-3: 295-309.
5. Wang, Xiaosong, et al. Cylindrical block copolymer micelles and co-micelles of controlled length and architecture. Science2007, 5838: 644-647.
6. O’Reilly, et al. Cross-linked block copolymer micelles: functional nanostructures of great potential and versatility.Chemical Society Reviews, 2006, 11: 1068-1083.