Cyclodextrins Modified/Coated Metal-Organic Frameworks

Zhang, HC; Liu, ZN; Shen, J

Abstract

Recent progress about a novel organic-inorganic hybrid materials, namely cyclodextrins (CDs) modified/coated metal-organic frameworks (MOFs) is summarized by using a special categorization method focusing on the interactions between CDs and MOFs moieties, such as ligand-metal cations interactions, supramolecular interactions including host-guest interactions and hydrogen bonding, as well as covalent bonds. This review mainly focuses on the interactions between CDs and MOFs and the strategy of combining them together, diverse external stimuli responsiveness of CDs-modified/coated MOFs, as well as applications of these hybrid materials to drug delivery and release system, catalysis and detection materials. Additionally, due to the importance of investigating advanced chemical architectures and physiochemical properties of CDs-modified/coated MOFs, a separate section is involved in diverse characterization methods and instruments. Furthermore, this minireview also foresees future research directions in this rapidly developing field.

Keywords: metal-organic frameworks; cyclodextrins; modified; coated; hybrid materials; synthesis; applications

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Metal-organic Frameworks (MOFs) Materials

Cyclodextrin-modified metal-organic frameworks (CD-MOFs) represent an innovative approach in the field of drug delivery, combining the benefits of cyclodextrins and metal-organic frameworks (MOFs). Cyclodextrins, known for their ability to form inclusion complexes with various drug molecules, enhance the solubility and stability of drugs. When integrated into MOFs, which are known for their high porosity and large surface area, the resulting CD-MOFs offer a synergistic platform for efficient drug loading and controlled release. The modification with cyclodextrins imparts additional functionalities, such as improved biocompatibility and selective binding capabilities. This hybrid system allows for the encapsulation of a wide range of therapeutic agents, providing protection from degradation and controlled release triggered by environmental factors such as pH or temperature. CD-MOFs have shown significant potential in targeted drug delivery applications, particularly in cancer therapy, where they enhance the delivery of chemotherapeutic agents to tumor sites while minimizing systemic toxicity and side effects.