Improvement on stability, loading capacity and sustained release of rhamnolipids modified curcumin liposomes

Cheng, C; Wu, ZH; McClements, DJ; Zou, LQ; Peng, SF; Zhou, W; Liu, W

Abstract

A novel cholesterol-free curcumin delivery system was fabricated by rhamnolipids modified liposomes (RL-Lps). The incorporation of the rhamnolipids increased the sphericity, reduced the size, and decreased the polydispersity of the liposomes compared with pure liposomes (Lps). Analysis of the environmental stability of the RL-Lps showed they have good long-term stability over a wide range of pH (2-3 and 5-8), ionic strengths (0-200 mM), and accelerated centrifugal conditions. The curcumin-loaded rhamnolipids modified liposomes (Cur-RL-Lps) could be prepared with a relatively high loading efficiency (LE > 90%) and loading capacity (LC > 3.5%). The thermal and photochemical stability of the curcumin was improved after encapsulation in the Cur-RL-Lps. In vitro release studies indicated that the sustained release of the curcumin was prolonged when rhamnolipids were incorporated into the liposomes. This study shows that rhamnolipids have great potential for liposomal delivery system suitable for utilization in functional foods, dietary supplements, and pharmaceutical preparations.

Keywords: Liposomes; Rhamnolipids; Curumin; Stability; Sustained release

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Rhamnolipids modified curcumin liposomes are an innovative drug delivery system that enhances the therapeutic potential of curcumin, a compound known for its anti-inflammatory, antioxidant, and anticancer properties. Rhamnolipids, biosurfactants with excellent emulsifying and antimicrobial properties, are used to modify the surface of curcumin-loaded liposomes, improving their stability and bioavailability. This modification enhances the solubility of curcumin, a poorly water-soluble compound, and facilitates its targeted delivery to specific tissues or cells. The rhamnolipid coating also improves the interaction between the liposomes and cell membranes, promoting more efficient cellular uptake and sustained release of curcumin. This targeted approach not only increases the therapeutic efficacy of curcumin but also reduces potential side effects by minimizing off-target distribution. Rhamnolipids modified curcumin liposomes thus represent a promising strategy for developing more effective treatments for cancer, inflammatory diseases, and other conditions.