CD Bioparticles is a high-tech company that integrates professional R&D, production and sales to provide customized solutions for the development and production of drug delivery systems (DDS) and new medical materials.
CD Bioparticles is a leading global supplier of PEG derivatives with a dedicated research team and strong technical capabilities. These derivatives are manufactured under ISO9001 and ISO13485 compliance, and operate according to ICH Q7A guidelines to produce PEG derivatives. CD Bioparticles is committed to providing PEG raw material, high purity PEG derivatives, custom PEG synthesis and PEGylation services to customers worldwide. These PEG derivatives are used in a wide range of pharmaceuticals, sustained release, drug delivery, medical diagnostics, etc.
Today we offer you:
Fully certified high-quality PEG derivatives. They are an excellent choice for your PEG derivative supply if you seek to translate your R&D efforts into faster commercialization:
High-purity PEG derivatives with a wide variety of functional groups from R&D to commercial scale, in both non-GMP and GMP grades.
Large format, high purity PEG raw materials for chemical, biological, medical and commercial applications.
Custom PEG synthesis services to meet the unique needs of clients' projects.
Whenever you encounter any technical problems, we are always happy to provide you with scientific advice!
Table of Contents
PEGylation
LNPs Delivery System Excipients
PEG Linkers for ADC Drugs
PROTAC Linkers
PEG Hydrogels for Medical Devices
Dye Labeling
3D Printing
PEG Raw Materials
Featured Monodispersed Linear PEGs
Featured Heterobifunctional Linear PEGs
PEGylation
PEGylation is the covalent addition of PEG to another molecule, which is mainly coupled to peptides, proteins and antibody fragments in the biomedical field.
Significant pharmacological advantages of PEGylation peptides, proteins and antibody fragments include:
1) Improvement of drug solubility
2) Reduction of potential drug toxicity
3) Reduction of dosage frequency
4) Enhancement of drug stability, especially protection against protein drug degradation
Lipid nanoparticles (LNPs) are commonly used drug delivery systems in the field of nucleic acid drugs. The LNP technology is mainly developed for vaccine development.
Among them, PEG is commonly used to improve the stability of LNPs.
Antibody-drug conjugates (ADCs) are a class of targeted therapeutics for the treatment of cancer, consisting of monoclonal antibodies (Antibody) targeting tumor-specific or tumor-associated antigens coupled with different numbers of small molecule toxins (Payloads) via linkers. The chemistry of the linker affects various properties of ADCs, including toxicity, specificity, stability and potency.
PEG linkers are particularly attractive as linkers for antibody-drug couplers (ADCs):
1) Increase drug solubility and stability
2) Reduce toxicity
3) Reduce immunogenicity, improve pharmacokinetics and increase circulation time
Product Name
Structural Formula
Molecular weight
Purity
COOH-PEG4-NH2.HCl
301.81
≥95%
2-((Azido-PEG8-carbamoyl)methoxy)acetic acid
554.6
≥95%
mPEG25-SPA
1301
≥95%
Mal-PEG12-NHS
794
≥95%
Mal-NH-PEG8-COOH
592.6
≥95%
Alkyne-PEG4-NH2
231.3
≥95%
mPEG-SCM
-
≥95%
N3-PEG3-SPA
344.3
≥95%
Mal-PEG3-COOH
301.3
≥95%
N-(Hydroxy-peg3)-n-boc-peg4-t-butyl ester
597.74
≥95%
NH2-PEG12-OH
545.667
≥95%
mPEG36-NH2
1616.95
≥95%
PROTAC Linkers
PROTAC is a bifunctional molecule that efficiently and specifically catalyzes the degradation of disease-causing proteins. It consists of three parts: a target protein binding ligand at one end, an E3 ubiquitin ligand at the other end, and a linker chain in the middle.
PEG linkers are the most common motifs in the PROTAC linker structure.
Product Name
Structural Formula
Molecular weight
Purity
Tos-PEG3-O-C1-CH3COO
376.42
≥95%
Boc-NH-PEG2-Tos
403.49
≥95%
Tos-PEG2-NH2
259.32
≥95%
Thalidomide-O-PEG5-Tosyl
578.61
≥95%
Dox-Ph-PEG1-Cl
228.67
≥95%
NH2-Ph-C4-acid-NH2-Me
222.28
≥95%
Boc-NH-PEG2-C2-amido-C4-acid
376.45
≥95%
Boc-C1-PEG2-C4-Cl
294.81
≥95%
Thalidomide-O-amido-PEG3-NH2
506.509
≥95%
Tos-PEG4-Tos
502.6
≥95%
Boc-NH-PEG3-OH
249.3
≥95%
Pomalidomide-PEG4-Ph-NH2
540.57
≥95%
PEG Hydrogels for Medical Devices
Multi-arm PEG derivatives are mostly employed in the formation of hydrogels. PEG hydrogels can be used to prepare drug slow-release systems, tissue engineering, cell culture, wound sealing, wound healing and so on. In drug slow-release systems, PEG-PLA hydrogels can be used as carriers to control the release rate of drugs. In tissue engineering, PEG-DA hydrogel can be used as the scaffold material for cell culture and tissue repair.
Product Name
Structural Formula
PEG MW
Purity
8-Arm-PEG-SS
5K, 10K, 20K, 40K Da
≥95%
8-Arm-PEG-SG
5K, 10K, 20K, 40K Da
≥95%
4-Arm-PEG-SS
2K, 5K, 10K, 20K, 40K Da
≥95%
4-Arm-PEG-SG
2K, 5K, 10K, 20K, 40K Da
≥95%
8-Arm-PEG-SH
10K, 20K, 40K Da
≥95%
Dye Labeling
PEGylated fluorescent dyes enhance specific tumor labeling. The PEG chains alter tissue biodistribution, allowing brighter liver metastases labeling and decreased accumulation in normal organs, particularly the liver.
3D Printing
3D printing has become a promising frontier in the field of complex tissue engineering due to its porosity, biodegradability and good biocompatibility. PEG derivatives are particularly attractive in three-dimensional printing due to their good biocompatibility under both in vitro and in vivo conditions.
Product Name
Structural Formula
PEG MW
AC-PEG-RGD
2K, 3.4K, 5K Da
8-Arm-PEG-Acrylate
5K, 10K, 20K, 40K Da
ACRL-PEG-ACRL
400, 600, 800, 1k, 2K, 3.4K, 5K, 10K, 20K Da
PEG Raw Materials
CD Bioparticles provides high purity PEG raw materials (linear and multi-arm PEG) for chemical, biological, medical and industrial applications in batch sizes of 5kg, 15kg, 20kg and 100kg. These PEG raw materials are suitable for further derivatization into PEG derivatives.
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