PEG Linkers for ADCs Development
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CD Bioparticles is a high-tech company integrating professional R&D, production, and sales, providing customized solutions for the development and production of drug delivery systems (DDS) and new medical materials.
CD Bioparticles is a leading global supplier of PEG linkers with a dedicated research team and strong technical capabilities. Those derivatives are manufactured under ISO9001 and ISO13485 compliance, and is operating according to ICH Q7A guidelines to produce PEG linkers. CD Bioparticles is committed to providing high purity PEG linkers to customers worldwide. These PEG linkers have been widely used for drug discovery, biocoupling and labeling, and nanoparticle drug delivery. In particular, it has become an extremely important research tool as ADC drug development.
Today we offer you:
A fully certified high-quality PEG linkers, which can be used in many different fields, such as ADC linker. This is an excellent choice for your PEG linkers supply if you seek to translate your R&D efforts into faster commercialization:
- Providing high-purity PEG linkers with a wide variety of functional groups from R&D to commercial scale, in both non-GMP and GMP grades.
- Providing custom PEG linkers synthesis services to meet the unique needs of clients’ projects.
- Whenever you encounter any technical problems, we look forward to providing you with scientific guidance at any time!
Introduction to ADC Drugs
Antibody-drug conjugates (ADCs) are a class of targeted therapeutics for the treatment of cancer, consisting of monoclonal antibodies (Antibody) targeting tumor-specific or tumor-associated antigens coupled with different numbers of small molecule cytotoxic drug (Payloads) via linkers.
A superior ADC linker can help antibodies to selectively deliver and accurately release cytotoxic drugs at the tumor site. In addition, it plays critical roles in ADCs stability during preparation, storage and circulation. A stable ADC drug ensures that less cytotoxic payload is reduced before it reaches the tumor cell, thereby improving safety and limiting dose.
Fig. 1. Schematic diagram of ADC represents the key components and their significant role.
PEG Linkers for ADC Drugs
The PEG linker has become an attractive tool for bio-coupling, drug delivery and ADC development due to its water solubility and non-immunogenicity. PEG linkers are chemically functionalized polyethylene glycol (PEG) linkers. The use of various difunctionalized PEG linkers enables the formation of different types of ADC linkers by simple and rapid combinations with different structures. At the same time, it enables targeted coupling. In addition, the use of multibranched PEG derivatives not only increases the drug loading capacity, but also allows the construction of ADC molecules bearing multiple different toxins, which supports the development of a new generation of ADC drugs.
Fig. 2. Application of PEG Linkers in ADC Drugs.
PEG linkers are particularly attractive as linkers for antibody-drug couplers (ADCs):
1) Increase drug solubility and stability
2) Reduces toxicity
3) Reduces immunogenicity, improves pharmacokinetics and increases circulation time
| Featured Monofunctional PEG Linkers |
| Catalog |
Product Name |
Structural Formula |
MW |
Reactive Group |
| CDPB-04221 |
mPEG3-NH2 |
|
163.2 |
Carboxy、Hydroxyl、Isocyanato |
| CDPB-04233 |
mPEG36-NH2 |
|
1616.95 |
Carboxy、Hydroxyl、Isocyanato |
| CDPB-041021 |
mPEG7-SPA |
|
509.6 |
Amine |
| CDP23-0318 |
mPEG10-SPA |
|
645 |
Amine |
| CDPB-041025 |
mPEG11-SPA |
|
685.75 |
Amine |
| CDPB-041029 |
mPEG25-SPA |
|
1301 |
Amine |
| CDPB-041063 |
mPEG8-Aldehyde |
|
396.5 |
Amine、Aldehyde、Hydroxyl |
| CDBCP221 |
mPEG-SCM |
|
- |
Amine |
| CDPB-04836 |
Fmoc-NH-PEG3-COOH |
|
443.5 |
Amine、Hydroxyl |
| CDPB-04837 |
Fmoc-NH-PEG4-COOH |
|
487.6 |
Amine、Hydroxyl |
| CDN-04013 |
Fmoc-NH-PEG6-COOH |
|
575.6 |
Amine、Hydroxyl |
| CDPB-04841 |
Fmoc-NH-PEG8-COOH |
|
663.8 |
Amine、Hydroxyl |
| CDP23-0979 |
Fmoc-NH-PEG12-COOH |
|
839.963 |
Amine、Hydroxyl |
| CDPB-04635 |
N-(Hydroxy-peg3)-n-boc-PEG4-t-butyl ester |
|
597.74 |
Amine、Carboxy |
| CDPB-04167 |
Amino-PEG4-t-butyl ester |
|
321.4 |
Hydroxy、Isocyanato |
| Featured Bifunctional PEG Linkers |
| Catalog |
Product Name |
Structural Formula |
MW |
Reactive Group |
| CDPB-041311 |
Mal-NH-PEG8-COOH*1 |
|
592.6 |
Thiol、Amine、Dienophile |
| CDP23-1143 |
2-((Azide-PEG8-carbamoyl) methoxy)acetic acid*2 |
|
554.6 |
DBCO、BCN、Alkyne、Amine、Hydroxyl |
| CDPB-041285 |
Mal-PEG12-NHS*3 |
|
794 |
Thiol、Amine、Dienophile |
| CDPB-041278 |
MAL-PEG1-NHS ester*3 |
|
310.3 |
Thiol、Amine、Dienophile |
| CDPB-041272 |
Mal-PEG3-COOH*4 |
|
301.3 |
Amine、Hydroxyl、Dienophile |
| CDPB-04141 |
NH2-PEG4-COOH*5 |
|
265.3 |
Amine、Hydroxyl、Isocyanato、Carboxy |
| CDPB-04143 |
NH2-PEG6-COOH*5 |
|
353.4 |
Amine、Hydroxyl、Isocyanato、Carboxy |
| CDPB-04152 |
NH2-PEG24-COOH*5 |
|
1146 |
Amine、Hydroxyl、Isocyanato、Carboxy |
| CDPB-04156 |
NH2-PEG36-COOH*5 |
|
1675 |
Amine、Hydroxyl、Isocyanato、Carboxy |
| CDP23-0952 |
COOH-PEG4-NH2.HCl |
|
301.81 |
Amine、Hydroxyl |
| CDP23-0983 |
COOH-PEG24-NH2.HCl |
|
1182 |
Amine、Hydroxyl |
| CDPB-04050 |
Alkyne-PEG2-NH2 |
|
143.2 |
Azide、Isocyanato、Carboxy、Hydroxyl |
| CDPB-04052 |
Alkyne-PEG4-NH2 |
|
231.3 |
Azide、Isocyanato、Carboxy、Hydroxyl |
| Featured Bifunctional PEG Linkers |
| Catalog |
Product Name |
Structural Formula |
MW |
Reactive Group |
| CDPB-04055 |
Alkyne-PEG8-NH2 |
|
407.5 |
Azide、Carboxy、Hydroxyl、Isocyanato |
| CDP23-0541 |
N3-PEG3-SPA |
|
344.3 |
DBCO、BCN、Alkyne、Amine |
| CDP23-0319 |
OH-PEG6-OH |
|
282.331 |
Amine、Carboxy |
| CDP23-0380 |
OH-PEG8-OH |
|
370.436 |
Amine、Carboxy |
| CDP23-0379 |
OH-PEG9-OH |
|
414.488 |
Amine、Carboxy |
| CDPB-04179 |
NH2-PEG4-OH |
|
193.2 |
Amine、Hydroxyl、Carboxy、Isocyanato |
| CDPB-04182 |
NH2-PEG7-OH |
|
325.4 |
Amine、Hydroxyl、Carboxy、Isocyanato |
| CDPB-04187 |
NH2-PEG12-OH |
|
545.667 |
Amine、Carboxy、Hydroxyl、Isocyanato |
| CDN-04015 |
N3-PEG2-NH2 |
|
174.2 |
DBCO、BCN、Alkyne、Hydroxyl、Isocyanato、Carboxy |
| CDPB-041117 |
N3-PEG2-COOH |
|
203.2 |
Amine、Hydroxyl、DBCO、BCN、Alkyne |
| CDPB-041119 |
N3-PEG4-COOH |
|
291.3 |
Amine、Hydroxyl、DBCO、BCN、Alkyne |
| CDPB-041122 |
N3-PEG8-COOH |
|
467.5 |
Amine、Hydroxyl、DBCO、BCN、Alkyne |
| CDPB-041123 |
N3-PEG9-COOH |
|
511.6 |
Amine、Hydroxyl、DBCO、BCN、Alkyne |
| CDPB-041124 |
N3-PEG10-COOH |
|
555.62 |
Amine、Hydroxyl、DBCO、BCN、Alkyne |
| Featured Bifunctional PEG Linkers |
| Catalog |
Product Name |
Structural Formula |
MW |
Reactive Group |
| CDPB-04557 |
N-(acid-PEG3)-N-Bis(PEG3-Azide) |
|
623.7 |
Amine、Hydroxyl、DBCO、BCN、Alkyne |
| CDN1801 |
OH-PEG-NH2 |
|
- |
Amine、Carboxy、Isocyanato |
| CDP23-0233 |
OH-PEG-AA |
|
- |
Amine、Hydroxyl、Carboxy |
| CDPB-04910 |
OH-PEG4-Tos |
|
348.4 |
Amine、Carboxy |
| CDP23-0677 |
COOH-PEG-COOH |
|
- |
Amine、Hydroxyl |
Note: Products marked with "*" are ADC linkers used in marketed drugs or research papers.
1. ADC Therapeutics, Inc. Zynlonta, first FDA-approved ADC targeting CD19.
2. Gilead Trodelvy®, FDA-approved ADC for the treatment of mTNBC.
3. Trastuzumab-PEG24-DM1 (DOI: 10.1016/j.jconrel.2021.07.041)
4. Ab-PEG4-Mal-DM1 (DOI: 10.1158/0008-5472.CAN-09-3546)
5. Trastuzumab-conjugated ADCs (DIO: 10.1016/j.bmc.2021.116497)
