CD Bioparticles' services with customized delivery strategies, precise designs and modifications of drugs or drug-contained cargos, and advanced technical platforms can help you to solve:
The challenges you might meet:
- Limited preformulated drug-loaded liposomes for your in vitro and in vivo studies
- Complicated formulation of the drug-loaded liposomes with optimized loading yield of different drug molecules
- Limited options for tracking and detection of cell uptake (e.g. macrophage) experiments
- Fast clearance of the drug-loaded liposomes for in vivo studies
- Low cell specific targeting or tissue specific targeting of the drug-loaded liposomes
- Tedious drug-loaded liposome formulation, purifications, and production
Drug Loaded Liposomes Key features:
- Liposomal ATP
- PEGylated Liposomal ATP
- Negatively Charged
- Neutral Charged
- Positively Charged
- Non- PEGylated Liposomal ATP
- Negatively Charged
- Neutral Charged
- Positively Charged
- Fluorescent Liposomal ATP
- Liposomal encapsulated ATP preventing cell death and tissue dysfunction
- Liposomal DOTA
- DOTA encapsulated liposomes are used for remote loading of radioactive divalent ions such as radioactive copper into the liposomes.
- Liposomal Topotecan
- Liposomal Paxlitaxel
- Liposomal Irinotecan
- Liposomal Clodronate
- Control of Clodronate Encapsulated Liposomes
- Neutral Liposomal Clodronate
- Anionic Liposomal Clodronate
- Fluorescent Liposomal Clodronate, covering the entire spectrum
- The Liposomal Clodronate targets the macrophage cells, then releases clodronate into the cytosol, resulting in cell death, as well as the macrophage depletion
- Liposomal Doxorubicin
- Non-surface Reactive Liposomal Doxorubicin
- PEGylated Non-Surface Reactive Liposomal Doxorubicin
- Non-PEGylated Non-Surface Reactive Liposomal Doxorubicin
- Non-PEGylated Liposomal Doxorubicin for Post-insertion of PEG lipid Conjugated Ligands
- Surface Reactive Liposomal Doxorubicin
- Amine Reactive
- Biotinylated
- Carboxylic Acid Reactive
- DBCO or Azide Reactive
- Folate Reactive
- Sulfhydryl Reactive
- Liposomal Alendronate
- Control of Alendronate Encapsulated Liposomes
- Neutral Liposomal Alendronate
- Anionic Liposomal Alendronate
- The liposomal encapsulation efficiency of alendronate is no less than 90%
- Liposomal alendronate depletes monocytes and macrophages efficiently
- Liposomes for Drug Loading
- Ammonium Gradient Liposomes for Active Loading
- Liposomes for Loading Hydrophobic Drugs
- Those pre-formed liposome products are created for post loading of drug molecules
Drug Loaded Liposomes Key benefits:
- Wide coverage of pre-formulated drug-loaded liposomes
- Maximum drug/lipid ratio at which no or minimal drug crystals seen
- The final formulation could be sterile filtered for long term storage
- Surface active liposomes allowing the modification of the drug-loaded liposomes to achieve cell-targeting or tissue-targeting
- Post-drug-loading liposomes allowing customized drug loading
- Fluorescent drug-loaded liposomes allowing tracking the drug-delivery/cell-uptake process
- Enhanced aqueous solubility of water insoluble compounds
- Improved stability over other drug solubility vehicles
- Potential prolonged in vivo systemic circulation (slow release)
- Suitable for in vitro and in vivo experiments
- Ready-to-use
Drug Loaded Liposomes Application candidates:
- Drug models of in vitro or in vivo studies of the chemotherapy
- Macrophage depletion to achieve immune deficient animal models
- Tracking and detection of cell uptake (e.g. macrophage)
- Long circulation applications
- Cell-targeting or tissue targeting drug delivery
