Cyclodextrin Inclusion Compounds

Cyclodextrin Inclusion Compounds (CICs) have emerged as a pioneering and versatile strategy in the realm of drug delivery, revolutionizing the pharmaceutical landscape. Cyclodextrins, cyclic oligosaccharides composed of glucose units, serve as unique molecular hosts with a hydrophobic interior and hydrophilic exterior. This inherent structural characteristic enables cyclodextrins to form inclusion complexes with a diverse array of guest molecules, encapsulating them within their central cavities.

One of the distinctive features of Cyclodextrin Inclusion Compounds lies in their ability to enhance the solubility and stability of poorly water-soluble drugs, thereby addressing significant challenges in drug formulation. The hydrophobic guest molecules are enveloped by the hydrophilic cyclodextrin, resulting in improved aqueous solubility and bioavailability. This property proves invaluable in optimizing drug delivery systems, facilitating better absorption and therapeutic efficacy.

Furthermore, the tunable nature of cyclodextrins allows for the design of tailored inclusion complexes, influencing drug release kinetics and providing sustained or controlled release profiles. The biocompatibility and low toxicity of cyclodextrins further contribute to their appeal in pharmaceutical formulations.