Peptide-based Systems for Drug Delivery

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CD Bioparticles is a supplier specializing in peptides. We offer customized peptide production services based on the effects of the peptides.

CD Bioparticles is a leading global peptide supplier with a dedicated research team and strong technical capabilities. Peptides possess diversity and great potential in the field of drug delivery. They play an important role in improving drug efficacy, reducing side effects and realizing targeted delivery. With the deepening of research, the application of peptides in the field of drug delivery is promising. As carriers, peptides can be designed to be able to self-assemble to form micelles or hydrogels to encapsulate drugs. Cell-Penetrating Peptides (CPPs), carry various drugs into cells. Many CPPs are able to cross the blood-brain barrier (BBB) and target gliomas. As tumor-targeting peptides, they are able to selectively interact with receptors overexpressed on the surface of tumor cells, enhancing tumor targeting and cellular uptake. As stimulus-responsive fragments in drug carriers, peptides can be altered in response to physiological features typical of the tumor microenvironment, such as low pH, high concentrations of reduced glutathione and high levels of specific enzymes. Such alterations have great potential to improve tumor targeting efficiency. CD Bioparticles can help you solve a wide range of tricky problems in peptide-based production with one-to-one customization.

Today we offer you:

With the advancement in drug delivery system (DDS) development, CD Bioparticles have achieved significant research results in the field of peptide-dependent drug delivery systems. We can provide you with a variety of services related to peptide-based drug delivery systems to meet your research needs and pilot phase.

Peptide product customization
Peptide conjugation services
Analysis in vivo and in vitro of peptide conjugation products

Advantages of peptides
List of peptide products

Advantages of Peptides

Improve drug effects and reduce side effects

Peptides are easy to synthesize, easy to metabolize, have low immunogenicity, and have low toxicity and side effects, which can effectively improve the effect of drugs and reduce the dosage and toxicity of drugs in drug delivery systems.

Targeting and penetration

Peptides can be used as targeting and penetrating peptides to help drugs reach the lesion site more precisely, improve therapeutic effects and reduce side effects.

Responsive drug delivery

Peptides can be designed as responsive peptides to achieve response to environmental changes (e.g. pH changes, enzyme activity and redox properties, etc.), thereby releasing drugs under specific conditions and improving the precision and efficiency of drug delivery.

Self-assembly properties and nanostructure formation (carriers)

Peptides are capable of self-assembling to form nanostructures, which significantly enhance the stability of peptide drug delivery systems and allows for long-lasting release.

Improvement of physicochemical and biological properties of drugs

Peptides as building blocks for nanodrugs have the properties of good biocompatibility, self-assembly and chemical variability, which provide a new direction for the construction of smart nano-delivery systems.

High drug loading and bioavailability

Peptide drug conjugates (PDCs) as prodrugs can improve the bioavailability of difficult-to-solve drugs, enhance the selectivity of chemotherapeutic drugs, prolong the duration of drug action, etc., and significantly improve the physicochemical and biopharmacological properties of drugs.

Biocompatibility and biodegradability

Synthetic peptides, as biocompatible and biodegradable macromolecules, can vary in composition and structure over a wide range, providing diverse options for drug delivery.

Part of Peptide Products

Catalog	Products	Structure
CDCCP23-001L	740 Y-P	RQIKIWFQNRRMKWKKSDGG-{Tyr(PO2)}-MDMS
CDCCP23-008L	iRGD Peptide	CRGDKGPDC (Disulfide bridge:Cys1-Cys9)
CDCCP23-028L	iRGD Peptide 1 TFA	CRGDKGPDC (TFA sult)
CDCCP23-031L	PBP10 TFA	RhB-QRLFQVKGRR-OH
CDCCP23-036L	RGD	RGD
CDCCP23-041L	TAT (48-57)	GRKKRRQRRR
CDCCP23-046L	(Arg)9 Acetate	RRRRRRRRR
CDCCP23-059L	(Arg)9, FAM-labeled	FAM-RRRRRRRRR
CDCCP23-060L	Biotin-TAT (47-57)	{Biotin}-YGRKKRRQRRR
CDCCP23-065L	HXR9	WYPWMKKHHRRRRRRRRR
CDCCP23-076L	Antennapedia Leader Peptide (CT)	KKWKMRRNQFWVKVQRG
CDCCP23-090L	TfR-T12	THRPPMWSPVWP
CDCCP23-103L	Activable Cell-Penetrating Peptide (ACCP)	DGGDGGDGGDGPLGLAG-{d-Arg}-C
CDCCP23-113L	SynB1	RGGRLSYSRRRFSTSTGRA

References

Gao Z, et al.; Polypeptide nanoparticles with pH-sheddable PEGylation for improved drug delivery. Langmuir. 2020, 36(45) : 13656-13662.
Xing R, et al.; Self-assembled injectable peptide hydrogels capable of triggering antitumor immune response. Biomacromolecules. 2017, 18(11) : 3514-3523.
Li Z, et al.; Cell penetrating peptide modified M2 macrophage derived exosomes treat spinal cord injury and rheumatoid arthritis by loading curcumin. Materials & Design. 2017, 225: 111455-111466.
Cai Y, et al.; Tumor-targeting peptide functionalized PEG-PLA micelles for efficient drug delivery. Biomaterials Science. 2020, 8: 2274-2282.
Jiang XL, et al.; Self-assembled peptide nanoparticles responsive to multiple tumor microenvironment triggers provide highly efficient targeted delivery and release of antitumor drug. Journal of Controlled Release. 2019, 316: 196-207.

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Peptide-based Systems for Drug Delivery

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Table of Contents

Advantages of Peptides

Part of Peptide Products