pH-responsive copolymers have been extensively researched and utilized in drug delivery systems due to their ability to undergo changes in response to fluctuations in pH. These copolymers are designed to be stable at one pH range but become soluble, undergo swelling, or exhibit changes in shape or charge at a different pH range. This property allows for targeted and controlled drug release in specific environments of the body, such as tumor regions or the acidic environment of the stomach. pH-responsive copolymers in drug delivery offer a promising strategy for improving site-specific drug release, enhancing therapeutic efficacy, and minimizing off-target side effects.