Phosphoramidite monomer

Phosphoramidite monomers play an important role in transfection. These specialized molecules are key elements in the synthesis of synthetic oligonucleotides, such as short interfering RNA (siRNA) and antisense oligonucleotides, which are essential for manipulating gene expression in research and different treatment.

Phosphoramidite monomers were chemically engineered to facilitate solid-phase synthesis of these custom oligonucleotides, allowing precise control of sequence composition. They serve as the basis for the formation of phosphodiester bonds, allowing the assembly of chains capable of selectively targeting and regulating specific genes.This technology has enormous potential in genetic research, gene therapy and drug development, providing a versatile and powerful tool to understand and regulate cellular processes at the molecular level.