| CAS No. | 219989-84-1 |
| Description | PEGylated liposomes containing Ixabepilone (BMS-247550). Ixabepilone is a semi-synthetic analog of epothilone B which binds tubulin and promotes tubulin polymerization and microtubule stabilization, causing cell cycle arrest in the G2-M phase and inducing tumor cell apoptosis. Compared to taxanes, epothilones have higher affinity for β-tubulin and are not P-gp substrates. Thus, Ixabepilone can inhibit growth of tumor cells which are resistant to taxanes and/or anthracyclines due to increased P-gp. This product is a pre-formulated liposomal version of Ixabepilone which is supplied ready to use in vitro or in vivo. The liposomes are PEGylated for optimal in vivo performance. For preclinical research use only. |
| Lipid composition | PEGylated Liposomes |
| Liposome Size | 70-120 nm |
| Lipid Molar Concentration | 60 mM |
| Shelf-life | At least 1 month |
| Encapsulated Drug | Ixabepilone |
| Drug concentration | 2.5 mg/mL (± ~5%) |
| Inside Buffer | 292 mM sucrose, 0.5% DPBS (1X) |
| Outside Buffer | 292 mM sucrose, 0.5% DPBS (1X) |
| Storage | 2 °C to 8 °C (do not freeze), protect from light |
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×| Product Name | Catalog | Lipid composition | Liposome Size | Price |
|---|---|---|---|---|
| Clipos™ Lxabepilone (BMS-247550) Encapsulated Liposomes | CDEPG-19 | HSPC/Chol/DSPE-mPEG2000 (56.2/38.5/5.3 molar ratio) | 70-120 nm | $2200 |
| Clipos™ Lxabepilone (BMS-247550) Encapsulated Liposomes | CDEPG-21 | PEGylated Liposomes | 70-120 nm | $2300 |
| Clipos™ Lxabepilone (BMS-247550) Encapsulated Liposomes | CDEPG-28 | PEGylated Liposomes | 70-120 nm | $1380 |
| Clipos™ Lxabepilone (BMS-247550) Encapsulated Liposomes | CDEPG-24 | PEGylated Liposomes | 70-120 nm | $4500 |
| Clipos™ Lxabepilone (BMS-247550) Encapsulated Liposomes | CDEPG-25 | PEGylated Liposomes | 70-120 nm | $4500 |
| Clipos™ Lxabepilone (BMS-247550) Encapsulated Liposomes | CDEPG-27 | PEGylated Liposomes | 70-120 nm | $4500 |
| Clipos™ Lxabepilone (BMS-247550) Encapsulated Liposomes | CDEPG-31 | PEGylated Liposomes | 70-120 nm | INQUIRY |
| Clipos™ Lxabepilone (BMS-247550) Encapsulated Liposomes | CDEPG-32 | PEGylated Liposomes | 70-120 nm | $1380 |
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Datasheet