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Clipos™ Lxabepilone (BMS-247550) Encapsulated Liposomes

Catalog:CDEPG-20

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Storage2 °C to 8 °C (do not freeze), protect from light
CAS No.219989-84-1
DescriptionPEGylated liposomes containing Ixabepilone (BMS-247550). Ixabepilone is a semi-synthetic analog of epothilone B which binds tubulin and promotes tubulin polymerization and microtubule stabilization, causing cell cycle arrest in the G2-M phase and inducing tumor cell apoptosis. Compared to taxanes, epothilones have higher affinity for β-tubulin and are not P-gp substrates. Thus, Ixabepilone can inhibit growth of tumor cells which are resistant to taxanes and/or anthracyclines due to increased P-gp. This product is a pre-formulated liposomal version of Ixabepilone which is supplied ready to use in vitro or in vivo. The liposomes are PEGylated for optimal in vivo performance. For preclinical research use only.
Lipid compositionPEGylated Liposomes
Liposome Size70-120 nm
Lipid Molar Concentration60 mM
Shelf-lifeAt least 1 month
Encapsulated DrugIxabepilone
Drug concentration2.5 mg/mL (± ~5%)
Inside Buffer292 mM sucrose, 0.5% DPBS (1X)
Outside Buffer292 mM sucrose, 0.5% DPBS (1X)
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