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Clipos™ Gilteritinib (ASP2215) Encapsulated Liposomes


Catalog:CDEPG-19

Unit Size
Price
$2200

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Storage2 °C to 8 °C (do not freeze), stored under nitrogen
CAS No.1254053-43-4
DescriptionGilteritinib (ASP2215) is a small-molecule inhibitor of FLT3/AXL with IC50 values of 0.29 nM and 0.73 nM for FLT3 and AXL, respectively. Gilteritinib (ASP2215) is a highly selective FLT3 inhibitor that demonstrates activity against both FLT3-ITD and FLT3-TKD mutation subtypes and selectively inhibits FLT3 at concentrations roughly 800-fold lower than those required to inhibit c-Kit (230 nM). This product is a pre-formulated liposomal version of Gilteritinib (ASP2215) which is supplied ready to use in vitro or in vivo. The liposomes are PEGylated for optimal in vivo performance; the lipid composition of the liposomes is the same as Doxil. For preclinical research use only.
Lipid compositionHSPC/Chol/DSPE-mPEG2000 (56.2/38.5/5.3 molar ratio)
Liposome Size70-120 nm
Lipid Molar Concentration26.4 mM
Shelf-lifeAt least 3 months
Encapsulated DrugGilteritinib
Drug concentration2.5 mg/mL
Inside Buffer250 mM ammonium sulfate, pH 5.5
Outside BufferDPBS (1X), pH 7.4
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