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Clipos™ Adavosertib Encapsulated Liposomes


Catalog:CDEPG-34

Unit Size
Price
$2200

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Storage2 °C to 8 °C (do not freeze)
CAS No.955365-80-7
DescriptionPEGylated liposomes containing Wee-1 kinase inhibitor adavosertib (MK1775; AZD1775), remote loaded by an ammonium sulfate gradient. The lipid composition of the liposomes is the same as Doxil. Sterile filtered and supplied ready for use in preclinical studies in rodents or in vitro. Adavosertib is a potent, ATP-competitive Wee-1 kinase inhibitor, which hinders the G2 DNA damage response checkpoint and is reported to enhance cytotoxic effects of several compounds including 5-FU and NSC 613327. For preclinical research use only.
Lipid compositionHSPC/Chol/DSPE-mPEG2000 (56.2/38.5/5.3 molar ratio)
Liposome Size70-120 nm
Lipid Molar Concentration27.2 mM
Shelf-life6 months
Encapsulated DrugAdavosertib
Drug concentration1.0 mg/mL
Inside Buffer250 mM Ammonium Sulfate, pH 5.5
Outside BufferNormal Saline (154 mM NaCl, pH 5.5)
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