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Clipos™ SP600125 Encapsulated Liposomes


Catalog:CDEPG-22

Unit Size
Price
$4500

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Storage2 °C to 8 °C (do not freeze), protect from light
CAS No.129-56-6
DescriptionPEGylated liposomes containing JNK inhibitor SP600125 (Nsc75890). SP600125 is a reversible, ATP-competitive broad-spectrum JNK inhibitor (JNK1/JNK2, IC50 40 nM; JNK3, IC50 90 nM). with IC50s of 40, 40 and 90 nM for JNK1, JNK2 and JNK3, respectively. SP600125 is also a broad‐spectrum inhibitor of serine/threonine kinases including Aurora kinase A, FLT3 and TRKA. SP600125 inhibits ferroptosis, autophagy, and activates apoptosis. SP600125 is insoluble in aqueous media. This product is a pre-formulated liposomal version of Sp600125 which is supplied ready to use in vitro or in vivo. The liposomes are PEGylated for optimal in vivo performance. For preclinical research use only.
Lipid compositionPEGylated Liposomes
Liposome Size70-120 nm
Lipid Molar Concentration60 mM
Shelf-lifeAt least 1 month
Encapsulated DrugSP600125
Drug concentration250 mcg/mL
Inside Buffer292 mM sucrose, 0.5% DPBS (1X)
Outside Buffer292 mM sucrose, 0.5% DPBS (1X)
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