Storage | 2 °C to 8 °C (do not freeze), protect from light |
CAS No. | 129-56-6 |
Description | PEGylated liposomes containing JNK inhibitor SP600125 (Nsc75890). SP600125 is a reversible, ATP-competitive broad-spectrum JNK inhibitor (JNK1/JNK2, IC50 40 nM; JNK3, IC50 90 nM). with IC50s of 40, 40 and 90 nM for JNK1, JNK2 and JNK3, respectively. SP600125 is also a broad‐spectrum inhibitor of serine/threonine kinases including Aurora kinase A, FLT3 and TRKA. SP600125 inhibits ferroptosis, autophagy, and activates apoptosis. SP600125 is insoluble in aqueous media. This product is a pre-formulated liposomal version of Sp600125 which is supplied ready to use in vitro or in vivo. The liposomes are PEGylated for optimal in vivo performance. For preclinical research use only. |
Lipid composition | PEGylated Liposomes |
Liposome Size | 70-120 nm |
Lipid Molar Concentration | 60 mM |
Shelf-life | At least 1 month |
Encapsulated Drug | SP600125 |
Drug concentration | 250 mcg/mL |
Inside Buffer | 292 mM sucrose, 0.5% DPBS (1X) |
Outside Buffer | 292 mM sucrose, 0.5% DPBS (1X) |
Product Name | Catalog | Lipid composition | Liposome Size | Price |
---|---|---|---|---|
Clipos™ SP600125 Encapsulated Liposomes | CDEPG-20 | PEGylated Liposomes | 70-120 nm | INQUIRY |
Clipos™ SP600125 Encapsulated Liposomes | CDEPG-21 | PEGylated Liposomes | 70-120 nm | $2300 |
Clipos™ SP600125 Encapsulated Liposomes | CDEPG-23 | PEGylated Liposomes | 70-120 nm | INQUIRY |
Clipos™ SP600125 Encapsulated Liposomes | CDEPG-19 | HSPC/Chol/DSPE-mPEG2000 (56.2/38.5/5.3 molar ratio) | 70-120 nm | $2200 |
Clipos™ SP600125 Encapsulated Liposomes | CDEPG-27 | PEGylated Liposomes | 70-120 nm | $4500 |
Clipos™ SP600125 Encapsulated Liposomes | CDEPG-32 | PEGylated Liposomes | 70-120 nm | $1380 |
Clipos™ SP600125 Encapsulated Liposomes | CDEPG-29 | PEGylated Liposomes | 70-120 nm | $2200 |
Clipos™ SP600125 Encapsulated Liposomes | CDEPG-35 | HSPC/Chol/DSPE-mPEG2000 (56.2/38.5/5.3 molar ratio) | 70-120 nm | INQUIRY |
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