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Clipos™ Vincristine (NSC-67574) Encapsulated Liposomes


Catalog:CDEPG-35

Unit Size:

INQUIRY Datasheet

Storage2 °C to 8 °C (do not freeze)
CAS No. 2068-78-2
DescriptionVincristine (NSC-67574) sulfate is an antitumor vinca alkaloid which inhibits microtubule polymerization. and binds tubulin. Vincristine (NSC-67574) sulfate binds tubulin (IC50 32 μM) and causes cell cycle arrest (metaphase) and induces apoptosis. This product is a pre-formulated liposomal version of Vincristine (NSC-67574) sulfate which is supplied ready to use in vitro or in vivo. The liposomes are PEGylated for optimal in vivo performance; the lipid composition of the liposomes is the same as Doxil. For preclinical research use only.
Lipid compositionHSPC/Chol/DSPE-mPEG2000 (56.2/38.5/5.3 molar ratio)
Liposome Size70-120 nm
Lipid Molar Concentration26.4 mM
Shelf-lifeAt least 3 months
Encapsulated DrugVincristine
Drug concentration2.0 mg/mL
Inside Buffer250 mM ammonium sulfate, pH 5.5
Outside BufferDPBS (1X), pH 7.4
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